Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging - PubMed (original) (raw)

Review

doi: 10.1038/nrn2201.

Affiliations

• PMID: 17704812
• DOI: 10.1038/nrn2201

Review

Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging

Michael D Fox et al. Nat Rev Neurosci. 2007 Sep.

Abstract

The majority of functional neuroscience studies have focused on the brain's response to a task or stimulus. However, the brain is very active even in the absence of explicit input or output. In this Article we review recent studies examining spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal of functional magnetic resonance imaging as a potentially important and revealing manifestation of spontaneous neuronal activity. Although several challenges remain, these studies have provided insight into the intrinsic functional architecture of the brain, variability in behaviour and potential physiological correlates of neurological and psychiatric disease.

PubMed Disclaimer

Similar articles

• Disease and the brain's dark energy.
  Zhang D, Raichle ME. Zhang D, et al. Nat Rev Neurol. 2010 Jan;6(1):15-28. doi: 10.1038/nrneurol.2009.198. Nat Rev Neurol. 2010. PMID: 20057496 Review.
• How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations.
  Fransson P. Fransson P. Neuropsychologia. 2006;44(14):2836-45. doi: 10.1016/j.neuropsychologia.2006.06.017. Epub 2006 Aug 1. Neuropsychologia. 2006. PMID: 16879844
• How networks communicate: propagation patterns in spontaneous brain activity.
  Mitra A, Raichle ME. Mitra A, et al. Philos Trans R Soc Lond B Biol Sci. 2016 Oct 5;371(1705):20150546. doi: 10.1098/rstb.2015.0546. Philos Trans R Soc Lond B Biol Sci. 2016. PMID: 27574315 Free PMC article. Review.
• Physiological origin of low-frequency drift in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI).
  Yan L, Zhuo Y, Ye Y, Xie SX, An J, Aguirre GK, Wang J. Yan L, et al. Magn Reson Med. 2009 Apr;61(4):819-27. doi: 10.1002/mrm.21902. Magn Reson Med. 2009. PMID: 19189286
• Current trends and challenges in MRI acquisitions to investigate brain function.
  Sutton BP, Ouyang C, Karampinos DC, Miller GA. Sutton BP, et al. Int J Psychophysiol. 2009 Jul;73(1):33-42. doi: 10.1016/j.ijpsycho.2008.12.020. Epub 2009 Feb 21. Int J Psychophysiol. 2009. PMID: 19236896 Free PMC article. Review.

Cited by

• Defining language networks from resting-state fMRI for surgical planning--a feasibility study.
  Tie Y, Rigolo L, Norton IH, Huang RY, Wu W, Orringer D, Mukundan S Jr, Golby AJ. Tie Y, et al. Hum Brain Mapp. 2014 Mar;35(3):1018-30. doi: 10.1002/hbm.22231. Epub 2013 Jan 3. Hum Brain Mapp. 2014. PMID: 23288627 Free PMC article.
• Alterations in regional homogeneity of resting-state brain activity in mesial temporal lobe epilepsy.
  Zeng H, Pizarro R, Nair VA, La C, Prabhakaran V. Zeng H, et al. Epilepsia. 2013 Apr;54(4):658-66. doi: 10.1111/epi.12066. Epub 2013 Jan 7. Epilepsia. 2013. PMID: 23294137 Free PMC article.
• The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm.
  Licata SC, Nickerson LD, Lowen SB, Trksak GH, Maclean RR, Lukas SE. Licata SC, et al. Neuroimage. 2013 Apr 15;70:211-22. doi: 10.1016/j.neuroimage.2012.12.055. Epub 2013 Jan 5. Neuroimage. 2013. PMID: 23296183 Free PMC article.
• Path analysis: A method to estimate altered pathways in time-varying graphs of neuroimaging data.
  Falakshahi H, Rokham H, Fu Z, Iraji A, Mathalon DH, Ford JM, Mueller BA, Preda A, van Erp TGM, Turner JA, Plis S, Calhoun VD. Falakshahi H, et al. Netw Neurosci. 2022 Jul 1;6(3):634-664. doi: 10.1162/netn_a_00247. eCollection 2022 Jul. Netw Neurosci. 2022. PMID: 36204419 Free PMC article.
• Cerebral cartography and connectomics.
  Sporns O. Sporns O. Philos Trans R Soc Lond B Biol Sci. 2015 May 19;370(1668):20140173. doi: 10.1098/rstb.2014.0173. Philos Trans R Soc Lond B Biol Sci. 2015. PMID: 25823870 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information