Mice left out in the cold: commentary on the phenotype of TRPM8-nulls - PubMed (original) (raw)

Review

Mice left out in the cold: commentary on the phenotype of TRPM8-nulls

Richard L Daniels et al. Mol Pain. 2007.

Abstract

Detection of innocuous temperatures allows an organism to select an appropriate environmental climate, while the ability to recognize noxious temperature extremes warns of impending tissue damage. For temperatures considered cold, the menthol receptor TRPM8 is activated when temperatures drop below approximately 26 degrees C, thus making it an intriguing candidate as the molecular mediator of cold perception. However, confirmation of this hypothesis in vivo has eluded researchers until recently. Three independent research groups have reported that mice lacking this single gene are severely impaired in their ability to detect cold temperatures. Remarkably, these animals are deficient in many diverse aspects of cold signaling, including cool and noxious cold perception, injury-evoked sensitization to cold, and cooling-induced analgesia. These animals provide a great deal of insight into the molecular signaling pathways that participate in the detection of cold and painful stimuli.

PubMed Disclaimer

Cited by

Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons.
Takashima Y, Daniels RL, Knowlton W, Teng J, Liman ER, McKemy DD. Takashima Y, et al. J Neurosci. 2007 Dec 19;27(51):14147-57. doi: 10.1523/JNEUROSCI.4578-07.2007. J Neurosci. 2007. PMID: 18094254 Free PMC article.
Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation.
Kono T, Satomi M, Suno M, Kimura N, Yamazaki H, Furukawa H, Matsubara K. Kono T, et al. Brain Behav. 2012 Jan;2(1):68-73. doi: 10.1002/brb3.34. Brain Behav. 2012. PMID: 22574275 Free PMC article.
Design and construction of a two-temperature preference behavioral assay for undergraduate neuroscience laboratories.
Daniels RL, McKemy DD. Daniels RL, et al. J Undergrad Neurosci Educ. 2010 Fall;9(1):A51-6. Epub 2010 Oct 15. J Undergrad Neurosci Educ. 2010. PMID: 23494724 Free PMC article.
Scraping through the ice: uncovering the role of TRPM8 in cold transduction.
McCoy DD, Knowlton WM, McKemy DD. McCoy DD, et al. Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1278-87. doi: 10.1152/ajpregu.00631.2010. Epub 2011 Mar 16. Am J Physiol Regul Integr Comp Physiol. 2011. PMID: 21411765 Free PMC article. Review.
A spicy family tree: TRPV1 and its thermoceptive and nociceptive lineage.
McKemy DD. McKemy DD. EMBO J. 2011 Feb 2;30(3):453-5. doi: 10.1038/emboj.2010.350. EMBO J. 2011. PMID: 21285975 Free PMC article.

References

1. Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007 - PubMed
1. Colburn RW, Lubin ML, Stone DJ, Jr., Wang Y, Lawrence D, D'Andrea MR, Brandt MR, Liu Y, Flores CM, Qin N. Attenuated cold sensitivity in TRPM8 null mice. Neuron. 2007;54:379–386. doi: 10.1016/j.neuron.2007.04.017. - DOI - PubMed
1. Dhaka A, Murray AN, Mathur J, Earley TJ, Petrus MJ, Patapoutian A. TRPM8 is required for cold sensation in mice. Neuron. 2007;54:371–378. doi: 10.1016/j.neuron.2007.02.024. - DOI - PubMed
1. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997;389:816–824. doi: 10.1038/39807. - DOI - PubMed
1. Tominaga M, Caterina MJ. Thermosensation and pain. J Neurobiol. 2004;61:3–12. doi: 10.1002/neu.20079. - DOI - PubMed

Mice left out in the cold: commentary on the phenotype of TRPM8-nulls - PubMed (original) (raw)