Implications of a histone code mimic in epigenetic signaling - PubMed (original) (raw)
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. 2007 Aug 17;27(4):521-2.
doi: 10.1016/j.molcel.2007.08.002.
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- PMID: 17707224
- DOI: 10.1016/j.molcel.2007.08.002
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Implications of a histone code mimic in epigenetic signaling
Christopher H Henkels et al. Mol Cell. 2007.
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Abstract
In this issue of Molecular Cell, Sampath et al. show a lysine methylase exhibits substrate promiscuity and variability in degree of product methylation (Sampath et al., 2007). Two lysines are found to be automethylated in G9a, and one is H3K9-like and can establish a docking site for HP1 chromodomain.
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- Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly.
Sampath SC, Marazzi I, Yap KL, Sampath SC, Krutchinsky AN, Mecklenbräuker I, Viale A, Rudensky E, Zhou MM, Chait BT, Tarakhovsky A. Sampath SC, et al. Mol Cell. 2007 Aug 17;27(4):596-608. doi: 10.1016/j.molcel.2007.06.026. Mol Cell. 2007. PMID: 17707231
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