Calnexin, calreticulin and the folding of glycoproteins - PubMed (original) (raw)
Calnexin, calreticulin and the folding of glycoproteins
No authors listed. Trends Cell Biol. 1997 May.
Free article
Abstract
Calnexin and calreticulin are molecular chaperones in the endoplasmic reticulum (ERJ. They are lectins that interact with newly synthesized glycoproteins that have undergone partial trimming of their core N-linked oligosaccharides. Together with the enzymes responsible for glucose removal and a glucosyltransferase that re-glucosylates already-trimmed glycoproteins, they provide a novel mechanism for promoting folding, oligomeric assembly and quality control in the ER.
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