Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM - PubMed (original) (raw)

Comment

. 2007 Aug 24;317(5841):1036; author reply 1036.

doi: 10.1126/science.1141705.

Affiliations

• PMID: 17717170
• DOI: 10.1126/science.1141705

Comment

Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM

Nicholas Timpson et al. Science. 2007.

Abstract

Evans et al. and Mekel-Bobrov et al. (Reports, 9 September 2005, p. 1717 and 1720, respectively) reported that human genetic variants of Microcephalin (MCPH1) and abnormal spindle-like microcephaly associated (ASPM) are under strong positive selection. We genotyped these variants in 9000 children and find no meaningful associations with brain size and various cognitive measures, which indicates that contrary to previous speculations, ASPM and MCPH1 have not been selected for brain-related effects.

PubMed Disclaimer

Comment on

• Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.
  Evans PD, Gilbert SL, Mekel-Bobrov N, Vallender EJ, Anderson JR, Vaez-Azizi LM, Tishkoff SA, Hudson RR, Lahn BT. Evans PD, et al. Science. 2005 Sep 9;309(5741):1717-20. doi: 10.1126/science.1113722. Science. 2005. PMID: 16151009
• Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.
  Mekel-Bobrov N, Gilbert SL, Evans PD, Vallender EJ, Anderson JR, Hudson RR, Tishkoff SA, Lahn BT. Mekel-Bobrov N, et al. Science. 2005 Sep 9;309(5741):1720-2. doi: 10.1126/science.1116815. Science. 2005. PMID: 16151010

Similar articles

• Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens" and "Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans".
  Currat M, Excoffier L, Maddison W, Otto SP, Ray N, Whitlock MC, Yeaman S. Currat M, et al. Science. 2006 Jul 14;313(5784):172; author reply 172. doi: 10.1126/science.1122822. Science. 2006. PMID: 16840683
• Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".
  Yu F, Hill RS, Schaffner SF, Sabeti PC, Wang ET, Mignault AA, Ferland RJ, Moyzis RK, Walsh CA, Reich D. Yu F, et al. Science. 2007 Apr 20;316(5823):370. doi: 10.1126/science.316.5823.370a. Science. 2007. PMID: 17446375
• The derived allele of ASPM is associated with lexical tone perception.
  Wong PC, Chandrasekaran B, Zheng J. Wong PC, et al. PLoS One. 2012;7(4):e34243. doi: 10.1371/journal.pone.0034243. Epub 2012 Apr 17. PLoS One. 2012. PMID: 22529908 Free PMC article.
• Molecular genetic determinants of human brain size.
  Tang BL. Tang BL. Biochem Biophys Res Commun. 2006 Jul 7;345(3):911-6. doi: 10.1016/j.bbrc.2006.05.040. Epub 2006 May 15. Biochem Biophys Res Commun. 2006. PMID: 16716254 Review.
• Evolution of primary microcephaly genes and the enlargement of primate brains.
  Ponting C, Jackson AP. Ponting C, et al. Curr Opin Genet Dev. 2005 Jun;15(3):241-8. doi: 10.1016/j.gde.2005.04.009. Curr Opin Genet Dev. 2005. PMID: 15917198 Review.

Cited by

• Genetic Primary Microcephalies: When Centrosome Dysfunction Dictates Brain and Body Size.
  Farcy S, Hachour H, Bahi-Buisson N, Passemard S. Farcy S, et al. Cells. 2023 Jul 7;12(13):1807. doi: 10.3390/cells12131807. Cells. 2023. PMID: 37443841 Free PMC article. Review.
• Tone and genes: New cross-linguistic data and methods support the weak negative effect of the "derived" allele of ASPM on tone, but not of Microcephalin.
  Dediu D. Dediu D. PLoS One. 2021 Jun 30;16(6):e0253546. doi: 10.1371/journal.pone.0253546. eCollection 2021. PLoS One. 2021. PMID: 34191836 Free PMC article.
• _ASPM_-lexical tone association in speakers of a tone language: Direct evidence for the genetic-biasing hypothesis of language evolution.
  Wong PCM, Kang X, Wong KHY, So HC, Choy KW, Geng X. Wong PCM, et al. Sci Adv. 2020 May 27;6(22):eaba5090. doi: 10.1126/sciadv.aba5090. eCollection 2020 May. Sci Adv. 2020. PMID: 32537487 Free PMC article.
• Insights into body size variation in cetaceans from the evolution of body-size-related genes.
  Sun Y, Liu Y, Sun X, Lin Y, Yin D, Xu S, Yang G. Sun Y, et al. BMC Evol Biol. 2019 Jul 27;19(1):157. doi: 10.1186/s12862-019-1461-9. BMC Evol Biol. 2019. PMID: 31351448 Free PMC article.
• Evolution of ASPM coding variation in apes and associations with brain structure in chimpanzees.
  Singh SV, Staes N, Guevara EE, Schapiro SJ, Ely JJ, Hopkins WD, Sherwood CC, Bradley BJ. Singh SV, et al. Genes Brain Behav. 2019 Sep;18(7):e12582. doi: 10.1111/gbb.12582. Epub 2019 Jun 11. Genes Brain Behav. 2019. PMID: 31119860 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon