Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample - PubMed (original) (raw)

doi: 10.1097/YPG.0b013e3280c1e5fb.

Rami Abou Jamra, Katrin Klein, Angela Wolf Villela, Johannes Schumacher, Tim Becker, Torsten Paul, Christine Schmael, Susanne Höfels, Norman Klopp, Thomas Illig, Peter Propping, Sven Cichon, Markus M Nöthen, Thomas G Schulze, Marcella Rietschel

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Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample

Alexander Georgi et al. Psychiatr Genet. 2007 Oct.

Abstract

Genetic variation in glutamatergic signalling pathways is believed to play a substantial role in the aetiology of schizophrenia. The N-methyl-D-aspartate receptor subunit gene GRIN1 has been proposed as a candidate gene for schizophrenia. We tested for a potential association between schizophrenia and four single nucleotide polymorphisms (rs4880213, rs11146020, rs6293, and rs10747050) and one microsatellite marker at GRIN1 in a German sample of 354 patients and 323 controls. We found significant associations in single-marker and haplotype-based analyses (P<0.05). Significance was more pronounced (P<0.01) in the subset of patients with a lifetime history of major depression, a subgroup of schizophrenia described previously as a promising phenotypic subtype in genetic studies of schizophrenia. Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia.

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