There's more than one way to skin a chimaerin - PubMed (original) (raw)

Comment

There's more than one way to skin a chimaerin

Matthew B Dalva. Neuron. 2007.

Abstract

In two manuscripts published in Neuron (Beg et al. and Wegmeyer et al.) and one published in Cell (Iwasato et al.), investigators have found that a particular GAP, alpha-chimaerin, is required in vivo for ephrinB3/EphA4-dependent motor circuit formation.

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Figures

Figure 1. Model for α2-Chimaerin Activity in EphrinB3/EphA4 Forward Signaling

(A) EphrinB3 mediated axon guidance via EphA4 and α2-chimaerin in axonal process of cortical projection neurons. (B) EphrinB3 binds to EphA4. α2-Chimaerin binds to EphA4, and, in the presence of ephrinB3, its RAC-inactivating activity is increased. Chimaerin’s RAC-inactivation activity is also modulated with Nck2. EphA4s interact with RhoGEFs that may participate in other aspects of growth cone guidance. (C) Loss of ephrinB3, EphA4, or α-chimaerin leads to defects in gait resulting from axonal projection defects. Interestingly, only defects in guidance due to ephrinB3/EphA4 forward signaling are phenocopied by the loss of α-chimaerin.

Comment on

• EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin.
  Wegmeyer H, Egea J, Rabe N, Gezelius H, Filosa A, Enjin A, Varoqueaux F, Deininger K, Schnütgen F, Brose N, Klein R, Kullander K, Betz A. Wegmeyer H, et al. Neuron. 2007 Sep 6;55(5):756-67. doi: 10.1016/j.neuron.2007.07.038. Neuron. 2007. PMID: 17785182
• alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits.
  Beg AA, Sommer JE, Martin JH, Scheiffele P. Beg AA, et al. Neuron. 2007 Sep 6;55(5):768-78. doi: 10.1016/j.neuron.2007.07.036. Neuron. 2007. PMID: 17785183

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References

1. 1. Beg AA, Sommer JE, Martin JH, Scheiffele P. Neuron. 2007;55:768–778. this issue. - PubMed
2. 1. Brown M, Jacobs T, Eickholt B, Ferrari G, Teo M, Monfries C, Qi RZ, Leung T, Lim L, Hall C. J Neurosci. 2004;24:8994–9004. - PMC - PubMed
3. 1. Buttery P, Beg AA, Chih B, Broder A, Mason CA, Scheiffele P. Proc Natl Acad Sci USA. 2006;103:1924–1929. - PMC - PubMed
4. 1. Coonan JR, Greferath U, Messenger J, Hartley L, Murphy M, Boyd AW, Dottori M, Galea MP, Bartlett PF. J Comp Neurol. 2001;436:248–262. - PubMed
5. 1. Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. Neuron. 2005;46:205–217. - PubMed

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