From induced to programmed lymphoid tissues: the long road to preempt pathogens - PubMed (original) (raw)
From induced to programmed lymphoid tissues: the long road to preempt pathogens
Gérard Eberl. Trends Immunol. 2007 Oct.
Abstract
In mammalian fetuses, ontogeny dictates the development of secondary lymphoid tissues, the spleen, the lymph nodes and the Peyer's patches. In adults, commensals, infectious microbes and inflammation induce the formation of small reversible lymphoid tissues resembling lymph nodes or Peyer's patches. Crucial to lymphoid-tissue genesis is lymphotoxin-beta receptor-mediated activation of inflammatory effectors and structural chemokines. This pathway might have existed since the advent of the vertebrate lymphocyte system to organize local adaptive immunity in response to microbes; however, it only operates in the absence of microbes in mammals, resulting in the development of secondary lymphoid tissues and in preempting pathogens.
Similar articles
- Role of chemokines in the development of secondary and tertiary lymphoid tissues.
Cupedo T, Mebius RE. Cupedo T, et al. Semin Immunol. 2003 Oct;15(5):243-8. doi: 10.1016/j.smim.2003.08.002. Semin Immunol. 2003. PMID: 15001173 Review. - Organogenesis of lymphoid tissues.
Mebius RE. Mebius RE. Nat Rev Immunol. 2003 Apr;3(4):292-303. doi: 10.1038/nri1054. Nat Rev Immunol. 2003. PMID: 12669020 Review. - Role of lymphotoxins in the development of Peyer's patches and mesenteric lymph nodes: relevance to intestinal inflammation and treatment.
Spahn TW, Müller MK, Domschke W, Kucharzik T. Spahn TW, et al. Ann N Y Acad Sci. 2006 Aug;1072:187-93. doi: 10.1196/annals.1326.029. Ann N Y Acad Sci. 2006. PMID: 17057199 Review. - Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation--opposite functions for surface lymphotoxin expressed by T and B lymphocytes.
Jungbeck M, Stopfer P, Bataille F, Nedospasov SA, Männel DN, Hehlgans T. Jungbeck M, et al. Mol Immunol. 2008 Jan;45(1):34-41. doi: 10.1016/j.molimm.2007.05.007. Epub 2007 Jun 27. Mol Immunol. 2008. PMID: 17590442 - Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.
Bouskra D, Brézillon C, Bérard M, Werts C, Varona R, Boneca IG, Eberl G. Bouskra D, et al. Nature. 2008 Nov 27;456(7221):507-10. doi: 10.1038/nature07450. Epub 2008 Nov 5. Nature. 2008. PMID: 18987631
Cited by
- Lymphatic vessels and tertiary lymphoid organs.
Ruddle NH. Ruddle NH. J Clin Invest. 2014 Mar;124(3):953-9. doi: 10.1172/JCI71611. Epub 2014 Mar 3. J Clin Invest. 2014. PMID: 24590281 Free PMC article. Review. - Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
Cherrier M, Sawa S, Eberl G. Cherrier M, et al. J Exp Med. 2012 Apr 9;209(4):729-40. doi: 10.1084/jem.20111594. Epub 2012 Mar 19. J Exp Med. 2012. PMID: 22430492 Free PMC article. - The use of BLT humanized mice to investigate the immune reconstitution of the gastrointestinal tract.
Wahl A, Victor Garcia J. Wahl A, et al. J Immunol Methods. 2014 Aug;410:28-33. doi: 10.1016/j.jim.2014.06.009. Epub 2014 Jun 18. J Immunol Methods. 2014. PMID: 24952245 Free PMC article. Review. - Commensal microbiota influence systemic autoimmune responses.
Van Praet JT, Donovan E, Vanassche I, Drennan MB, Windels F, Dendooven A, Allais L, Cuvelier CA, van de Loo F, Norris PS, Kruglov AA, Nedospasov SA, Rabot S, Tito R, Raes J, Gaboriau-Routhiau V, Cerf-Bensussan N, Van de Wiele T, Eberl G, Ware CF, Elewaut D. Van Praet JT, et al. EMBO J. 2015 Feb 12;34(4):466-74. doi: 10.15252/embj.201489966. Epub 2015 Jan 19. EMBO J. 2015. PMID: 25599993 Free PMC article. - A defining factor for natural killer cell development.
Di Santo JP. Di Santo JP. Nat Immunol. 2009 Oct;10(10):1051-2. doi: 10.1038/ni1009-1051. Nat Immunol. 2009. PMID: 19767724 No abstract available.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources