Gene conversion: mechanisms, evolution and human disease - PubMed (original) (raw)
Review
doi: 10.1038/nrg2193. Epub 2007 Sep 11.
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- PMID: 17846636
- DOI: 10.1038/nrg2193
Review
Gene conversion: mechanisms, evolution and human disease
Jian-Min Chen et al. Nat Rev Genet. 2007 Oct.
Abstract
Gene conversion, one of the two mechanisms of homologous recombination, involves the unidirectional transfer of genetic material from a 'donor' sequence to a highly homologous 'acceptor'. Considerable progress has been made in understanding the molecular mechanisms that underlie gene conversion, its formative role in human genome evolution and its implications for human inherited disease. Here we assess current thinking about how gene conversion occurs, explore the key part it has played in fashioning extant human genes, and carry out a meta-analysis of gene-conversion events that are known to have caused human genetic disease.
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