Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent - PubMed (original) (raw)

Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent

Daniel J Simmonds et al. Neuropsychologia. 2008.

Abstract

FMRI studies of response inhibition consistently reveal frontal lobe activation. Localization within the frontal cortex, however, varies across studies and appears dependent on the nature of the task. Activation likelihood estimate (ALE) meta-analysis is a powerful quantitative method of establishing concurrence of activation across functional neuroimaging studies. For this study, ALE was used to investigate concurrent neural correlates of successfully inhibited No-go stimuli across studies of healthy adults performing a Go/No-go task, a paradigm frequently used to measure response inhibition. Due to the potential overlap of neural circuits for response selection and response inhibition, the analysis included only event-related studies contrasting No-go activation with baseline, which allowed for inclusion of all regions that may be critical to visually guided motor response inhibition, including those involved in response selection. These Go/No-go studies were then divided into two groups: "simple" Go/No-go tasks in which the No-go stimulus was always the same, and "complex" Go/No-go tasks, in which the No-go stimulus changed depending on context, requiring frequent updating of stimulus-response associations in working memory. The simple and complex tasks demonstrated distinct patterns of concurrence, with right dorsolateral prefrontal and inferior parietal circuits recruited under conditions of increased working memory demand. Common to both simple and complex Go/No-go tasks was concurrence in the pre-SMA and the left fusiform gyrus. As the pre-SMA has also been shown to be involved in response selection, the results support the notion that the pre-SMA is critical for selection of appropriate behavior, whether selecting to execute an appropriate response or selecting to inhibit an inappropriate response.

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Figures

Figure 1

Results of the ALE meta-analysis across all of the 11 Go/No-go studies. Images are shown in neurological orientation, such that the left side of the image corresponds to the left side of the brain. Representative slices in sagittal (top), coronal (middle) and axial (bottom) views are shown with Talairach planar coordinates above each slice, and the location of these slices can be seen in orthogonal views to the right of the figure. The analysis demonstrated a primarily right-lateralized network associated with successfully inhibited No-go stimuli, with concurrence seen in the rostral portion of the superior medial wall (pre-SMA; BA6/32), right prefrontal regions (BA9/10/44), left premotor cortex (BA6), bilateral inferior parietal regions (BA40), bilateral occipital regions (BA19/37), bilateral putamen and bilateral insula.

Figure 2

Results of the ALE analyses for the five “Simple” (top) and six “Complex” (middle) Go/No-go studies, and the overlap between the two types of studies (bottom). Images are shown in neurological orientation, such that the left side of the image corresponds to the left side of the brain. Representative slices in sagittal (left), coronal (middle) and axial (right) views are shown with Talairach planar coordinates above each slice. The ALE analyses of the “Simple” and “Complex” studies demonstrated distinct patterns of concurrence, with a right-lateralized prefrontal (BA9/44) / parietal (BA40) network seen only in the analysis of the complex tasks. Concurrence between the two analyses was localized to the pre-SMA (BA6/32, 176mm3 extent) and the left fusiform gyrus (BA37, 16mm3 extent), indicated by the arrows in the figure.

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Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent - PubMed (original) (raw)