Sweet taste signaling in the gut - PubMed (original) (raw)

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Sweet taste signaling in the gut

Anthony Sclafani. Proc Natl Acad Sci U S A. 2007.

No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.

T1R2+T1R3 sweet taste receptors are found in taste cells in the mouth and enteroendocrine cells in the gut. Stimulation of the T1R2+T1R3 receptors in the mouth by sugars and artificial sweeteners activates intracellular signaling elements, including α-gustducin (not shown), that trigger peripheral taste nerves and brain gustatory pathways. In the gut, stimulation of the T1R2+T1R3 receptors activates intracellular signaling elements, including α-gustducin (not shown), and causes the release of GLP-1 and GIP hormones. Among their many actions, these hormones stimulate the expression of SGLT1 in enterocytes, which, in turn, increases the absorption of glucose from the intestinal lumen.

Comment on

T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.
Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP. Margolskee RF, et al. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15075-80. doi: 10.1073/pnas.0706678104. Epub 2007 Aug 27. Proc Natl Acad Sci U S A. 2007. PMID: 17724332 Free PMC article.

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1. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KSH, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP. Proc Natl Acad Sci USA. 2007;104:15075–15080. - PMC - PubMed

Sweet taste signaling in the gut - PubMed (original) (raw)