Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth - PubMed (original) (raw)

. 2007 Oct 2;581(24):4754-60.

doi: 10.1016/j.febslet.2007.08.075. Epub 2007 Sep 6.

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Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth

Hiroaki Okuda et al. FEBS Lett. 2007.

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Abstract

The Drosophila planar cell polarity (PCP) gene prickle has been previously indicated as one of the regulators of gastrulation in the early embryonic stage. However, the functional role of prickle in the brain in particular is not known. We first indicated that mouse Prickle1 and Prickle2 are continually expressed in the brain throughout the embryonic stages and are observed to be specifically expressed in the postmitotic neurons. Furthermore, Prickle1 or Prickle2 depletion effectively decreases the neurite outgrowth levels of mouse neuroblastoma Neuro2a cells. These results indicate that mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development.

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