Chronic eosinophilic leukemias and the myeloproliferative variant of the hypereosinophilic syndrome - PubMed (original) (raw)
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Chronic eosinophilic leukemias and the myeloproliferative variant of the hypereosinophilic syndrome
Barbara J Bain et al. Immunol Allergy Clin North Am. 2007 Aug.
Abstract
Among patients with hypereosinophilia, a myeloproliferative variant is recognized. In many of these patients a diagnosis of eosinophilic leukemia can be made. The molecular mechanism is often a fusion gene, incorporating part of PDGFRA or PDGFRB, encoding anaberrant tyrosine kinase. Prompt diagnosis of such cases is important since specific tyrosine kinase inhibitor therapy is indicated.
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