Array-based comparative genomic hybridization: clinical contexts for targeted and whole-genome designs - PubMed (original) (raw)
Review
Array-based comparative genomic hybridization: clinical contexts for targeted and whole-genome designs
Swaroop Aradhya et al. Genet Med. 2007 Sep.
Free article
Abstract
Array-based comparative genomic hybridization is ushering in a new standard for analyzing the genome, overcoming the limits of resolution associated with conventional G-banded karyotyping. The first genomic arrays were based on bacterial artificial chromosome clones mapped during the initial phases of the Human Genome Project. These arrays essentially represented multiple fluorescence in situ hybridization assays performed simultaneously. The first arrays featured a targeted design, consisting of hundreds of bacterial artificial chromosome clones limited mostly to genomic regions of known medical significance. Then came whole-genome arrays, which contained bacterial artificial chromosome clones from across the entire genome. More recently, alternative designs based on oligonucleotide probes have been developed, and all these are high-density whole-genome arrays with resolutions between 3 and 35 kb. Certain clinical circumstances are well suited for investigation by targeted arrays, and there are others in which high-resolution whole-genome arrays are necessary. Here we review the differences between the two types of arrays and the clinical contexts for which they are best suited. As array-based comparative genomic hybridization is integrated into diagnostic laboratories and different array designs are used in appropriate clinical contexts, this novel technology will invariably alter the testing paradigm in medical genetics and will lead to the discovery of novel genetic conditions caused by chromosomal anomalies.
Similar articles
- Bacterial artificial chromosome-emulation oligonucleotide arrays for targeted clinical array-comparative genomic hybridization analyses.
Ou Z, Kang SH, Shaw CA, Carmack CE, White LD, Patel A, Beaudet AL, Cheung SW, Chinault AC. Ou Z, et al. Genet Med. 2008 Apr;10(4):278-89. doi: 10.1097/GIM.0b013e31816b4420. Genet Med. 2008. PMID: 18414211 Free PMC article. - Application of array-based comparative genomic hybridization to clinical diagnostics.
Bejjani BA, Shaffer LG. Bejjani BA, et al. J Mol Diagn. 2006 Nov;8(5):528-33. doi: 10.2353/jmoldx.2006.060029. J Mol Diagn. 2006. PMID: 17065418 Free PMC article. Review. - Detection of chromosomal imbalances in children with idiopathic mental retardation by array based comparative genomic hybridisation (array-CGH).
Schoumans J, Ruivenkamp C, Holmberg E, Kyllerman M, Anderlid BM, Nordenskjöld M. Schoumans J, et al. J Med Genet. 2005 Sep;42(9):699-705. doi: 10.1136/jmg.2004.029637. J Med Genet. 2005. PMID: 16141005 Free PMC article. - Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA.
Barrett MT, Scheffer A, Ben-Dor A, Sampas N, Lipson D, Kincaid R, Tsang P, Curry B, Baird K, Meltzer PS, Yakhini Z, Bruhn L, Laderman S. Barrett MT, et al. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17765-70. doi: 10.1073/pnas.0407979101. Epub 2004 Dec 10. Proc Natl Acad Sci U S A. 2004. PMID: 15591353 Free PMC article. - Microarray-based comparative genomic hybridization and its applications in human genetics.
Oostlander AE, Meijer GA, Ylstra B. Oostlander AE, et al. Clin Genet. 2004 Dec;66(6):488-95. doi: 10.1111/j.1399-0004.2004.00322.x. Clin Genet. 2004. PMID: 15521975 Review.
Cited by
- Genomic aspects in reproductive medicine.
Go M, Shim SH. Go M, et al. Clin Exp Reprod Med. 2024 Jun;51(2):91-101. doi: 10.5653/cerm.2023.06303. Epub 2024 Jan 24. Clin Exp Reprod Med. 2024. PMID: 38263590 Free PMC article. - In Silico Structural and Functional Analyses of NLRP3 Inflammasomes to Provide Insights for Treating Neurodegenerative Diseases.
Ghazi BK, Bangash MH, Razzaq AA, Kiyani M, Girmay S, Chaudhary WR, Zahid U, Hussain U, Mujahid H, Parvaiz U, Buzdar IA, Nawaz S, Elsadek MF. Ghazi BK, et al. Biomed Res Int. 2023 Jan 23;2023:9819005. doi: 10.1155/2023/9819005. eCollection 2023. Biomed Res Int. 2023. PMID: 36726838 Free PMC article. Retracted. - The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets.
Yang G, Lu T, Weisenberger DJ, Liang G. Yang G, et al. Genes (Basel). 2022 Aug 29;13(9):1555. doi: 10.3390/genes13091555. Genes (Basel). 2022. PMID: 36140723 Free PMC article. Review. - The prognostic significance of single-nucleotide polymorphism array-based whole-genome analysis and uniparental disomy in myelodysplastic syndrome.
Ou Y, Yang Y, Yu H, Zhang X, Liu M, Wu Y. Ou Y, et al. Int J Lab Hematol. 2021 Oct;43(5):1062-1069. doi: 10.1111/ijlh.13502. Epub 2021 Mar 2. Int J Lab Hematol. 2021. PMID: 33650312 Free PMC article. - Species and gene divergence in Littorina snails detected by array comparative genomic hybridization.
Panova M, Johansson T, Canbäck B, Bentzer J, Rosenblad MA, Johannesson K, Tunlid A, André C. Panova M, et al. BMC Genomics. 2014 Aug 18;15(1):687. doi: 10.1186/1471-2164-15-687. BMC Genomics. 2014. PMID: 25135785 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Research Materials