Incorporation and washout of n-3 polyunsaturated fatty acids after diet supplementation in clinical studies - PubMed (original) (raw)
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Incorporation and washout of n-3 polyunsaturated fatty acids after diet supplementation in clinical studies
Serge Masson et al. J Cardiovasc Med (Hagerstown). 2007 Sep.
Abstract
Current evidence suggests that at least part of the cardioprotective benefits of consumption of long-chain n-3 polyunsaturated fatty acids (PUFAs) relates to their incorporation into the phospholipids of cardiac cell membranes. Dietary supplementation with purified extracts of n-3 PUFAs derived from fish oil rapidly alters the composition of fatty acids in blood cell membranes and in other tissues. The present review summarises the time-course and dose-dependent incorporation and washout of n-3 PUFAs in the clinical setting and discusses the implications of these pharmacokinetic data in terms of biological effects.
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