Inflammation and cancer: an ancient link with novel potentials - PubMed (original) (raw)

Review

. 2007 Dec 1;121(11):2373-80.

doi: 10.1002/ijc.23173.

Affiliations

• PMID: 17893866
• DOI: 10.1002/ijc.23173

Review

Inflammation and cancer: an ancient link with novel potentials

S Perwez Hussain et al. Int J Cancer. 2007.

Abstract

Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g., cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post-translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer.

(c) 2007 Wiley-Liss, Inc.

PubMed Disclaimer

Similar articles

• The role of the mediators of inflammation in cancer development.
  Fernandes JV, Cobucci RN, Jatobá CA, Fernandes TA, de Azevedo JW, de Araújo JM. Fernandes JV, et al. Pathol Oncol Res. 2015 Jul;21(3):527-34. doi: 10.1007/s12253-015-9913-z. Epub 2015 Mar 5. Pathol Oncol Res. 2015. PMID: 25740073 Review.
• Chronic inflammation and oxidative stress in human carcinogenesis.
  Federico A, Morgillo F, Tuccillo C, Ciardiello F, Loguercio C. Federico A, et al. Int J Cancer. 2007 Dec 1;121(11):2381-6. doi: 10.1002/ijc.23192. Int J Cancer. 2007. PMID: 17893868 Review.
• Inflammation: gearing the journey to cancer.
  Kundu JK, Surh YJ. Kundu JK, et al. Mutat Res. 2008 Jul-Aug;659(1-2):15-30. doi: 10.1016/j.mrrev.2008.03.002. Epub 2008 Mar 16. Mutat Res. 2008. PMID: 18485806 Review.
• Possible contribution of chronic inflammation in the induction of cancer in rheumatic diseases.
  Cutolo M, Paolino S, Pizzorni C. Cutolo M, et al. Clin Exp Rheumatol. 2014 Nov-Dec;32(6):839-47. Epub 2014 Dec 9. Clin Exp Rheumatol. 2014. PMID: 25496746 Review.
• [Free radicals and antioxidants: physiology, human pathology and therapeutic aspects (part II)].
  Sahnoun Z, Jamoussi K, Zeghal KM. Sahnoun Z, et al. Therapie. 1998 Jul-Aug;53(4):315-39. Therapie. 1998. PMID: 9806002 Review. French.

Cited by

• HIPK2 in Colon Cancer: A Potential Biomarker for Tumor Progression and Response to Therapies.
  Verdina A, Garufi A, D'Orazi V, D'Orazi G. Verdina A, et al. Int J Mol Sci. 2024 Jul 12;25(14):7678. doi: 10.3390/ijms25147678. Int J Mol Sci. 2024. PMID: 39062921 Free PMC article. Review.
• Tristetraprolin: roles in cancer and senescence.
  Ross CR, Brennan-Laun SE, Wilson GM. Ross CR, et al. Ageing Res Rev. 2012 Sep;11(4):473-84. doi: 10.1016/j.arr.2012.02.005. Epub 2012 Feb 24. Ageing Res Rev. 2012. PMID: 22387927 Free PMC article. Review.
• The transient and constitutive inflammatory signaling in tumorigenesis.
  Rokavec M, Luo JL. Rokavec M, et al. Cell Cycle. 2012 Jul 15;11(14):2587-8. doi: 10.4161/cc.21139. Epub 2012 Jul 15. Cell Cycle. 2012. PMID: 22751429 Free PMC article.
• Inflammatory markers for predicting overall survival in gastric cancer patients: A systematic review and meta-analysis.
  Kim MR, Kim AS, Choi HI, Jung JH, Park JY, Ko HJ. Kim MR, et al. PLoS One. 2020 Jul 27;15(7):e0236445. doi: 10.1371/journal.pone.0236445. eCollection 2020. PLoS One. 2020. PMID: 32716955 Free PMC article.
• Cholesterol and Cytokines: Molecular Links to Atherosclerosis and Carcinogenesis.
  Suryan V, Chandra NC. Suryan V, et al. Cell Biochem Biophys. 2024 Sep;82(3):1837-1844. doi: 10.1007/s12013-024-01383-w. Epub 2024 Jun 28. Cell Biochem Biophys. 2024. PMID: 38943010 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database