Muscle strength is a marker of insulin resistance in patients with type 2 diabetes: a pilot study - PubMed (original) (raw)
doi: 10.1507/endocrj.k07-055. Epub 2007 Sep 25.
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- PMID: 17895577
- DOI: 10.1507/endocrj.k07-055
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Muscle strength is a marker of insulin resistance in patients with type 2 diabetes: a pilot study
Takuo Nomura et al. Endocr J. 2007 Dec.
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Abstract
To examine the effect of muscle strength on insulin resistance, we investigated the association between quantitative lower-extremity muscle strength and insulin resistance index as evaluated by homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes (20 men and 20 women, mean age SD: 53.3 12.7 years). By simple linear regression analyses, the knee extension force normalized for body weight (%KEF) was found to be significantly correlated with HOMA-IR in both male (r = -0.510, P<0.05) and female patients (r = -0.462, P<0.05). Stepwise regression analysis also showed that %KEF was an independent determinant of HOMA-IR (beta = -0.331, F = 5.400, P<0.005), as was BMI (beta = 0.409, F = 8.260, P<0.05). Our data suggest that lower-extremity muscle strength is independently associated with insulin resistance, which seems to be consistent with previous reports that resistance training improves glycemic control in type 2 diabetic patients. Further studies based on a larger study population will be required to confirm this possibility.
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