Neuronal regulation of alternative pre-mRNA splicing - PubMed (original) (raw)
Review
doi: 10.1038/nrn2237.
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- PMID: 17895907
- DOI: 10.1038/nrn2237
Review
Neuronal regulation of alternative pre-mRNA splicing
Qin Li et al. Nat Rev Neurosci. 2007 Nov.
Abstract
Alternative pre-mRNA splicing has an important role in the control of neuronal gene expression. Many neuronal proteins are structurally diversified through the differential inclusion and exclusion of sequences in the final spliced mRNA. Here, we discuss common mechanisms of splicing regulation and provide examples of how alternative splicing has important roles in neuronal development and mature neuron function. Finally, we describe regulatory proteins that control the splicing of some neuronally expressed transcripts.
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