Assessment of cumulative evidence on genetic associations: interim guidelines - PubMed (original) (raw)

Review

doi: 10.1093/ije/dym159. Epub 2007 Sep 26.

Paolo Boffetta, Julian Little, Thomas R O'Brien, Andre G Uitterlinden, Paolo Vineis, David J Balding, Anand Chokkalingam, Siobhan M Dolan, W Dana Flanders, Julian P T Higgins, Mark I McCarthy, David H McDermott, Grier P Page, Timothy R Rebbeck, Daniela Seminara, Muin J Khoury

Affiliations

• PMID: 17898028
• DOI: 10.1093/ije/dym159

Review

Assessment of cumulative evidence on genetic associations: interim guidelines

John P A Ioannidis et al. Int J Epidemiol. 2008 Feb.

Abstract

Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of 'strong', 'moderate' or 'weak' epidemiological credibility. In addition, we discuss how additional input and guidance can be derived from biological data. Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors.

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Comment in

• Commentary: Genetic association studies see light at the end of the tunnel.
  Frayling TM. Frayling TM. Int J Epidemiol. 2008 Feb;37(1):133-5. doi: 10.1093/ije/dym205. Epub 2007 Oct 5. Int J Epidemiol. 2008. PMID: 17921192 No abstract available.

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