Immigrating progenitor cells contribute to human podocyte turnover - PubMed (original) (raw)
. 2007 Dec;72(12):1468-73.
doi: 10.1038/sj.ki.5002524. Epub 2007 Sep 26.
Affiliations
- PMID: 17898701
- DOI: 10.1038/sj.ki.5002524
Free article
Immigrating progenitor cells contribute to human podocyte turnover
J U Becker et al. Kidney Int. 2007 Dec.
Free article
Abstract
Podocyte depletion is a critical event in glomerular diseases in general and in the development of focal segmental glomerulosclerosis in particular. Progenitor cell immigration is a possible mechanism of podocyte replacement for the preservation of nephron function since, with rare exception, mature podocytes are thought to be incapable of replication. We examined eight paraffin-embedded renal biopsies from six male recipients of female transplant kidneys for receiver-derived podocytes. Fluorescent in situ hybridization for the Y chromosome was combined with immunofluorescence for the podocyte marker, Wilms tumor-1 antigen. Recipient-derived podocytes were found in 4 of 8 biopsies representing 3 of the 6 patients. Overall, 5 of the 740 podocytes examined in the female-donated kidneys were male derived. Our study suggests that immigrating progenitor cells are able to replace podocytes in humans; however, the importance of this process in physiologic and pathologic conditions is unknown.
Similar articles
- Bone marrow-derived progenitor cells do not contribute to podocyte turnover in the puromycin aminoglycoside and renal ablation models in rats.
Meyer-Schwesinger C, Lange C, Bröcker V, Agustian P, Lehmann U, Raabe A, Brinkmeyer M, Kobayashi E, Schiffer M, Büsche G, Kreipe HH, Thaiss F, Becker JU. Meyer-Schwesinger C, et al. Am J Pathol. 2011 Feb;178(2):494-9. doi: 10.1016/j.ajpath.2010.10.024. Am J Pathol. 2011. PMID: 21281782 Free PMC article. - Mesenchymal stem cell therapy promotes renal repair by limiting glomerular podocyte and progenitor cell dysfunction in adriamycin-induced nephropathy.
Zoja C, Garcia PB, Rota C, Conti S, Gagliardini E, Corna D, Zanchi C, Bigini P, Benigni A, Remuzzi G, Morigi M. Zoja C, et al. Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1370-81. doi: 10.1152/ajprenal.00057.2012. Epub 2012 Sep 5. Am J Physiol Renal Physiol. 2012. PMID: 22952284 - [The role of podocyte damage in the pathogenesis of glomerulosclerosis and possible repair mechanisms].
Ronconi E, Mazzinghi B, Sagrinati C, Angelotti ML, Ballerini L, Parente E, Romagnani P, Lazzeri E, Lasagni L. Ronconi E, et al. G Ital Nefrol. 2009 Nov-Dec;26(6):660-9. G Ital Nefrol. 2009. PMID: 19918748 Review. Italian. - Progenitor cells and podocyte regeneration.
Shankland SJ, Pippin JW, Duffield JS. Shankland SJ, et al. Semin Nephrol. 2014 Jul;34(4):418-28. doi: 10.1016/j.semnephrol.2014.06.008. Epub 2014 Jun 13. Semin Nephrol. 2014. PMID: 25217270 Free PMC article. Review. - Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction.
Wiggins JE, Goyal M, Sanden SK, Wharram BL, Shedden KA, Misek DE, Kuick RD, Wiggins RC. Wiggins JE, et al. J Am Soc Nephrol. 2005 Oct;16(10):2953-66. doi: 10.1681/ASN.2005050488. Epub 2005 Aug 24. J Am Soc Nephrol. 2005. PMID: 16120818
Cited by
- Recruitment of podocytes from glomerular parietal epithelial cells.
Appel D, Kershaw DB, Smeets B, Yuan G, Fuss A, Frye B, Elger M, Kriz W, Floege J, Moeller MJ. Appel D, et al. J Am Soc Nephrol. 2009 Feb;20(2):333-43. doi: 10.1681/ASN.2008070795. Epub 2008 Dec 17. J Am Soc Nephrol. 2009. PMID: 19092119 Free PMC article. - Bone marrow-derived progenitor cells do not contribute to podocyte turnover in the puromycin aminoglycoside and renal ablation models in rats.
Meyer-Schwesinger C, Lange C, Bröcker V, Agustian P, Lehmann U, Raabe A, Brinkmeyer M, Kobayashi E, Schiffer M, Büsche G, Kreipe HH, Thaiss F, Becker JU. Meyer-Schwesinger C, et al. Am J Pathol. 2011 Feb;178(2):494-9. doi: 10.1016/j.ajpath.2010.10.024. Am J Pathol. 2011. PMID: 21281782 Free PMC article. - Podocyte biology for the bedside.
Jefferson JA, Alpers CE, Shankland SJ. Jefferson JA, et al. Am J Kidney Dis. 2011 Nov;58(5):835-45. doi: 10.1053/j.ajkd.2011.03.033. Epub 2011 Jun 29. Am J Kidney Dis. 2011. PMID: 21715071 Free PMC article. Review. - Podocyte repopulation contributes to regression of glomerular injury induced by ACE inhibition.
Macconi D, Sangalli F, Bonomelli M, Conti S, Condorelli L, Gagliardini E, Remuzzi G, Remuzzi A. Macconi D, et al. Am J Pathol. 2009 Mar;174(3):797-807. doi: 10.2353/ajpath.2009.080227. Epub 2009 Jan 22. Am J Pathol. 2009. PMID: 19164508 Free PMC article. - Diabetic nephropathy in American Indians, with a special emphasis on the Pima Indians.
Pavkov ME, Knowler WC, Hanson RL, Nelson RG. Pavkov ME, et al. Curr Diab Rep. 2008 Dec;8(6):486-93. doi: 10.1007/s11892-008-0083-1. Curr Diab Rep. 2008. PMID: 18990306 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical