Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs - PubMed (original) (raw)

. 2007 Nov;39(11):1318-20.

doi: 10.1038/ng.2007.4. Epub 2007 Sep 30.

Magnus Isaksson, Elinor K Karlsson, Eva Hellmén, Gerli Rosengren Pielberg, Peter Savolainen, Claire M Wade, Henrik von Euler, Ulla Gustafson, Ake Hedhammar, Mats Nilsson, Kerstin Lindblad-Toh, Leif Andersson, Göran Andersson

Affiliations

• PMID: 17906623
• DOI: 10.1038/ng.2007.4

Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs

Nicolette H C Salmon Hillbertz et al. Nat Genet. 2007 Nov.

Abstract

The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.

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