The phosphorylation state of Drp1 determines cell fate - PubMed (original) (raw)

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The phosphorylation state of Drp1 determines cell fate

Arezu Jahani-Asl et al. EMBO Rep. 2007 Oct.

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Figure 1

Figure 1

Missing links between mitochondrial fission and apoptosis. Cyclic-AMP-dependent protein kinase (PKA) phosphorylates dynamin-related protein 1 (Drp1) and induces mitochondrial elongation and resistance to apoptosis. Calcineurin dephosphorylates Drp1, promotes mitochondrial fragmentation and cell vulnerability to apoptosis. Whether phospho-Drp1 confers protection through inhibiting mitochondrial fission or through other regulatory signalling molecules remains to be discovered.

None

Arezu Jahani-Asl

None

Ruth S. Slack

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References

    1. Arnoult D, Rismanchi N, Grodet A, Roberts RG, Seeburg DP, Estaquier J, Sheng M, Blackstone C (2005) Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death. Curr Biol 15: 2112–2118 - PubMed
    1. Barsoum MJ et al. (2006) Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 25: 3900–3911 - PMC - PubMed
    1. Breckenridge DG, Stojanovic M, Marcellus RC, Shore GC (2003) Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J Cell Biol 160: 1115–1127 - PMC - PubMed
    1. Chan DC (2006) Mitochondria: dynamic organelles in disease, aging and development. Cell 125: 1241–1252 - PubMed
    1. Chang CR, Blackstone C (2007) Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. J Biol Chem 282: 21583–21587 - PubMed

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