Vascular permeability factor: a unique regulator of blood vessel function - PubMed (original) (raw)

Review

Vascular permeability factor: a unique regulator of blood vessel function

D T Connolly. J Cell Biochem. 1991 Nov.

Abstract

Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a potent polypeptide regulator of blood vessel function. VPF promotes an array of responses in endothelium, including hyperpermeability, endothelial cell growth, angiogenesis, and enhanced glucose transport. VPF regulates the expression of tissue factor and the glucose transporter. All of the endothelial cell responses to VPF are evidently mediated by high affinity cell surface receptors. Thus, endothelial cells have a unique and specific spectrum of responses to VPF. Since each of the responses of endothelial cells to VPF are also elicited by agonists, such as bFGF, TNF, histamine and others, it remains a major challenge to determine how post-receptor signalling pathways maintain both specificity and redundancy in cellular responses to various agonists.

PubMed Disclaimer

Similar articles

• Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.
  Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Senger DR, Dvorak HF. Brown LF, et al. Cancer Res. 1993 Oct 1;53(19):4727-35. Cancer Res. 1993. PMID: 8402650
• Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries.
  Couffinhal T, Kearney M, Witzenbichler B, Chen D, Murohara T, Losordo DW, Symes J, Isner JM. Couffinhal T, et al. Am J Pathol. 1997 May;150(5):1673-85. Am J Pathol. 1997. PMID: 9137092 Free PMC article.
• The in vivo bioactivity of vascular endothelial growth factor/vascular permeability factor is independent of N-linked glycosylation.
  Walter DH, Hink U, Asahara T, Van Belle E, Horowitz J, Tsurumi Y, Vandlen R, Heinsohn H, Keyt B, Ferrara N, Symes JF, Isner JM. Walter DH, et al. Lab Invest. 1996 Feb;74(2):546-56. Lab Invest. 1996. PMID: 8780172
• Lymphatic versus blood vascular endothelial growth factors and receptors in humans.
  Partanen TA, Paavonen K. Partanen TA, et al. Microsc Res Tech. 2001 Oct 15;55(2):108-21. doi: 10.1002/jemt.1162. Microsc Res Tech. 2001. PMID: 11596156 Review.
• [Lymphangiogenesis and biological activity ov vascular endothelial growth factor-C].
  Mandriota SJ, Pepper MS. Mandriota SJ, et al. J Soc Biol. 1999;193(2):159-63. J Soc Biol. 1999. PMID: 10451350 Review. French.

Cited by

• Concentration- and time-dependent response of human gingival fibroblasts to fibroblast growth factor 2 immobilized on titanium dental implants.
  Ma Q, Wang W, Chu PK, Mei S, Ji K, Jin L, Zhang Y. Ma Q, et al. Int J Nanomedicine. 2012;7:1965-76. doi: 10.2147/IJN.S29538. Epub 2012 Apr 17. Int J Nanomedicine. 2012. PMID: 22619534 Free PMC article.
• The Vascular Endothelium in Patients with Dengue Haemorrhagic Fever.
  Mutiara, Koh SCL, Bachtiar A, Hariman H. Mutiara, et al. Open Access Maced J Med Sci. 2019 Jul 12;7(14):2221-2225. doi: 10.3889/oamjms.2019.621. eCollection 2019 Jul 30. Open Access Maced J Med Sci. 2019. PMID: 31592071 Free PMC article.
• VEGF promotes malaria-associated acute lung injury in mice.
  Epiphanio S, Campos MG, Pamplona A, Carapau D, Pena AC, Ataíde R, Monteiro CA, Félix N, Costa-Silva A, Marinho CR, Dias S, Mota MM. Epiphanio S, et al. PLoS Pathog. 2010 May 20;6(5):e1000916. doi: 10.1371/journal.ppat.1000916. PLoS Pathog. 2010. PMID: 20502682 Free PMC article.
• Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A.
  Hu DE, Fan TP. Hu DE, et al. Br J Pharmacol. 1995 Jan;114(2):262-8. doi: 10.1111/j.1476-5381.1995.tb13221.x. Br J Pharmacol. 1995. PMID: 7533611 Free PMC article.
• Hypoxia-induced expression of vascular endothelial growth factor by retinal glial cells promotes in vitro angiogenesis.
  Hata Y, Nakagawa K, Ishibashi T, Inomata H, Ueno H, Sueishi K. Hata Y, et al. Virchows Arch. 1995;426(5):479-86. doi: 10.1007/BF00193171. Virchows Arch. 1995. PMID: 7543339

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database