Peptides derived from dolicholin, a phaseolin-like protein in country beans (Dolichos lablab), potently stimulate cholecystokinin secretion from enteroendocrine STC-1 cells - PubMed (original) (raw)
. 2007 Oct 31;55(22):8980-6.
doi: 10.1021/jf0719555. Epub 2007 Oct 4.
Affiliations
- PMID: 17914879
- DOI: 10.1021/jf0719555
Peptides derived from dolicholin, a phaseolin-like protein in country beans (Dolichos lablab), potently stimulate cholecystokinin secretion from enteroendocrine STC-1 cells
Md Kaosar Niaz Bin Sufian et al. J Agric Food Chem. 2007.
Abstract
Peptides derived from soybean beta-conglycinin and pork protein stimulate cholecystokinin (CCK) secretion from the enteroendocrine cells (EECs) and suppress food intake. Here we examined CCK-releasing activities from the enteroendocrine cell line STC-1, in peptides derived from underutilized legumes, and found much higher activity in the peptic hydrolysate of Country beans (CBP) compared to that from other legume-derived peptides including beta-conglycinin peptone. Active components in CBP were separated into acetonitrile-soluble fractions, but the activities were abolished after pronase treatment. To identify the Country bean protein containing the active peptides, Country bean protein extracts in an alkaline solution (CBE) were fractionated based on isoelectric point or molecular weight. Peptones prepared from CBE fractions containing a 51 kDa major protein stimulated CCK release, but other fractions did not. N-Terminal sequence analysis indicated that the 51 kDa protein is a phaseolin-like globular protein, and we designated this protein dolicholin. These results indicate that Country bean-derived peptides are very potent legume peptides in stimulating CCK secretion from EECs and that the stimulant peptides originate from dolicholin, a newly identified phaseolin-like globular protein in Country beans.
Similar articles
- Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells.
Nakajima S, Hira T, Hara H. Nakajima S, et al. Mol Nutr Food Res. 2012 May;56(5):753-60. doi: 10.1002/mnfr.201100666. Mol Nutr Food Res. 2012. PMID: 22648622 - Protein hydrolysates induce CCK release from enteroendocrine cells and act as partial agonists of the CCK1 receptor.
Foltz M, Ansems P, Schwarz J, Tasker MC, Lourbakos A, Gerhardt CC. Foltz M, et al. J Agric Food Chem. 2008 Feb 13;56(3):837-43. doi: 10.1021/jf072611h. Epub 2008 Jan 23. J Agric Food Chem. 2008. PMID: 18211011 - Potato extract (Potein) suppresses food intake in rats through inhibition of luminal trypsin activity and direct stimulation of cholecystokinin secretion from enteroendocrine cells.
Nakajima S, Hira T, Tsubata M, Takagaki K, Hara H. Nakajima S, et al. J Agric Food Chem. 2011 Sep 14;59(17):9491-6. doi: 10.1021/jf200988f. Epub 2011 Aug 16. J Agric Food Chem. 2011. PMID: 21809886 - Luminal CCK and its neuronal action on exocrine pancreatic secretion.
Zabielski R. Zabielski R. J Physiol Pharmacol. 2003 Dec;54 Suppl 4:81-94. J Physiol Pharmacol. 2003. PMID: 15075451 Review. - Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
EFSA GMO Panel Working Group on Animal Feeding Trials. EFSA GMO Panel Working Group on Animal Feeding Trials. Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. doi: 10.1016/j.fct.2008.02.008. Epub 2008 Feb 13. Food Chem Toxicol. 2008. PMID: 18328408 Review.
Cited by
- A comprehensive review on the glucoregulatory properties of food-derived bioactive peptides.
Jahandideh F, Bourque SL, Wu J. Jahandideh F, et al. Food Chem X. 2022 Feb 2;13:100222. doi: 10.1016/j.fochx.2022.100222. eCollection 2022 Mar 30. Food Chem X. 2022. PMID: 35498998 Free PMC article. - Can pulses play a role in improving cardiometabolic health? Evidence from systematic reviews and meta-analyses.
Viguiliouk E, Blanco Mejia S, Kendall CW, Sievenpiper JL. Viguiliouk E, et al. Ann N Y Acad Sci. 2017 Mar;1392(1):43-57. doi: 10.1111/nyas.13312. Epub 2017 Mar 2. Ann N Y Acad Sci. 2017. PMID: 28253436 Free PMC article. Review. - Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion.
Daly K, Al-Rammahi M, Moran A, Marcello M, Ninomiya Y, Shirazi-Beechey SP. Daly K, et al. Am J Physiol Gastrointest Liver Physiol. 2013 Feb 1;304(3):G271-82. doi: 10.1152/ajpgi.00074.2012. Epub 2012 Nov 29. Am J Physiol Gastrointest Liver Physiol. 2013. PMID: 23203156 Free PMC article. - Pulse consumption, satiety, and weight management.
McCrory MA, Hamaker BR, Lovejoy JC, Eichelsdoerfer PE. McCrory MA, et al. Adv Nutr. 2010 Nov;1(1):17-30. doi: 10.3945/an.110.1006. Epub 2010 Nov 16. Adv Nutr. 2010. PMID: 22043448 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources