Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends - PubMed (original) (raw)
. 2007 Nov 2;318(5851):798-801.
doi: 10.1126/science.1147182. Epub 2007 Oct 4.
Affiliations
- PMID: 17916692
- DOI: 10.1126/science.1147182
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends
Claus M Azzalin et al. Science. 2007.
Abstract
Telomeres, the DNA-protein complexes located at the end of linear eukaryotic chromosomes, are essential for chromosome stability. Until now, telomeres have been considered to be transcriptionally silent. We demonstrate that mammalian telomeres are transcribed into telomeric repeat-containing RNA (TERRA). TERRA molecules are heterogeneous in length, are transcribed from several subtelomeric loci toward chromosome ends, and localize to telomeres. We also show that suppressors with morphogenetic defects in genitalia (SMG) proteins, which are effectors of nonsense-mediated messenger RNA decay, are enriched at telomeres in vivo, negatively regulate TERRA association with chromatin, and protect chromosome ends from telomere loss. Thus, telomeres are actively transcribed into TERRA, and SMG factors represent a molecular link between TERRA regulation and the maintenance of telomere integrity.
Similar articles
- TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends.
Bettin N, Querido E, Gialdini I, Grupelli GP, Goretti E, Cantarelli M, Andolfato M, Soror E, Sontacchi A, Jurikova K, Chartrand P, Cusanelli E. Bettin N, et al. Sci Adv. 2024 Jun 14;10(24):eadk4387. doi: 10.1126/sciadv.adk4387. Epub 2024 Jun 12. Sci Adv. 2024. PMID: 38865460 Free PMC article. - The telomeric transcriptome and SMG proteins at the crossroads.
Chawla R, Azzalin CM. Chawla R, et al. Cytogenet Genome Res. 2008;122(3-4):194-201. doi: 10.1159/000167804. Epub 2009 Jan 30. Cytogenet Genome Res. 2008. PMID: 19188687 Review. - TERRA: telomeric repeat-containing RNA.
Luke B, Lingner J. Luke B, et al. EMBO J. 2009 Sep 2;28(17):2503-10. doi: 10.1038/emboj.2009.166. Epub 2009 Jul 23. EMBO J. 2009. PMID: 19629047 Free PMC article. Review. - MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.
Caslini C, Connelly JA, Serna A, Broccoli D, Hess JL. Caslini C, et al. Mol Cell Biol. 2009 Aug;29(16):4519-26. doi: 10.1128/MCB.00195-09. Epub 2009 Jun 15. Mol Cell Biol. 2009. PMID: 19528237 Free PMC article. - A human artificial chromosome recapitulates the metabolism of native telomeres in mammalian cells.
Wakai M, Abe S, Kazuki Y, Oshimura M, Ishikawa F. Wakai M, et al. PLoS One. 2014 Feb 18;9(2):e88530. doi: 10.1371/journal.pone.0088530. eCollection 2014. PLoS One. 2014. PMID: 24558398 Free PMC article.
Cited by
- lncRNA HOTAIR and Cardiovascular diseases.
Taghvimi S, Soltani Fard E, Khatami SH, Zafaranchi Z M S, Taheri-Anganeh M, Movahedpour A, Ghasemi H. Taghvimi S, et al. Funct Integr Genomics. 2024 Sep 19;24(5):165. doi: 10.1007/s10142-024-01444-6. Funct Integr Genomics. 2024. PMID: 39294422 Review. - Human sperm RNA in male infertility.
Cannarella R, Crafa A, Curto R, Mongioì LM, Garofalo V, Cannarella V, Condorelli RA, La Vignera S, Calogero AE. Cannarella R, et al. Nat Rev Urol. 2024 Sep 10. doi: 10.1038/s41585-024-00920-9. Online ahead of print. Nat Rev Urol. 2024. PMID: 39256514 Review. - Biomolecular condensates can enhance pathological RNA clustering.
Banerjee P, Mahendran TS, Wadsworth G, Singh A. Banerjee P, et al. Res Sq [Preprint]. 2024 Jul 19:rs.3.rs-4557520. doi: 10.21203/rs.3.rs-4557520/v1. Res Sq. 2024. PMID: 39070659 Free PMC article. Preprint. - Role of senataxin in R-loop-mediated neurodegeneration.
Kannan A, Gangadharan Leela S, Branzei D, Gangwani L. Kannan A, et al. Brain Commun. 2024 Jul 15;6(4):fcae239. doi: 10.1093/braincomms/fcae239. eCollection 2024. Brain Commun. 2024. PMID: 39070547 Free PMC article. Review. - MicroRNAs role in telomere length maintenance and telomerase activity in tumor cells.
Bortoletto S, Nunes-Souza E, Marchi R, Ruthes MO, Okano LM, Tofolo MV, Centa A, Fonseca AS, Rosolen D, Cavalli LR. Bortoletto S, et al. J Mol Med (Berl). 2024 Sep;102(9):1089-1100. doi: 10.1007/s00109-024-02467-z. Epub 2024 Jul 23. J Mol Med (Berl). 2024. PMID: 39042290 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases