Parkinson's disease: distribution of Lewy bodies and monoamine neuron system - PubMed (original) (raw)

Parkinson's disease: distribution of Lewy bodies and monoamine neuron system

E Ohama et al. Acta Neuropathol. 1976.

Abstract

A systematic study of the central and peripheral nervous systems in 3 cases of Parkinson's disease has demonstrated that Lewy bodies are present in 27 nuclei. Of these 20 nuclei (12 pigmented and 8 unpigmented) are involved in 2 or all 3 cases. It is noticed that the distribution of Lewy bodies in Parkinson's disease described here corresponds surprisingly well to that of monoamine (dopamine, noradrenaline and serotonin) cell bodies demonstrated in rats by the histochemical fluorescence method. This correlation is similar to that of Alzheimer's neurofibillary changes in postencephalitic Parkinsonism as described by Ishii. Inasmuch as these viewpoints are also in agreement with preciously reported biochemical data on Parkinsonism, it is suggested that Parkinsonism (idiopathic and postencephalitic) should represent a system degeneration of monoamine neuron systems.

PubMed Disclaimer

Similar articles

• Amine accumulation: a possible precursor of Lewy body formation in Parkinson's disease.
  Sandyk R, Willis GL. Sandyk R, et al. Int J Neurosci. 1992 Sep;66(1-2):61-74. doi: 10.3109/00207459208999790. Int J Neurosci. 1992. PMID: 1304571 Review.
• A pathological study of the association between Lewy body disease and Alzheimer's disease.
  Gibb WR, Mountjoy CQ, Mann DM, Lees AJ. Gibb WR, et al. J Neurol Neurosurg Psychiatry. 1989 Jun;52(6):701-8. doi: 10.1136/jnnp.52.6.701. J Neurol Neurosurg Psychiatry. 1989. PMID: 2545826 Free PMC article.
• Presenile dementia with Alzheimer-, Pick- and Lewy-body changes.
  Kosaka K, Oyanagi S, Matsushita M, Hori A. Kosaka K, et al. Acta Neuropathol. 1976 Nov 15;36(3):221-33. doi: 10.1007/BF00685366. Acta Neuropathol. 1976. PMID: 188300
• The Lewy body in Parkinson's disease.
  Forno LS. Forno LS. Adv Neurol. 1987;45:35-43. Adv Neurol. 1987. PMID: 3030070
• Dementia and Parkinson's disease--pathological and neurochemical considerations.
  Quinn NP, Rossor MN, Marsden CD. Quinn NP, et al. Br Med Bull. 1986 Jan;42(1):86-90. doi: 10.1093/oxfordjournals.bmb.a072104. Br Med Bull. 1986. PMID: 3006860 Review. No abstract available.

Cited by

• Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration.
  Gerard M, Deleersnijder A, Demeulemeester J, Debyser Z, Baekelandt V. Gerard M, et al. Mol Neurobiol. 2011 Aug;44(1):13-27. doi: 10.1007/s12035-011-8184-2. Epub 2011 May 7. Mol Neurobiol. 2011. PMID: 21553017 Review.
• Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for dementia with Lewy bodies and coincident Alzheimer's disease: An autopsy-confirmed study.
  Morimoto S, Takao M, Hatsuta H, Nishina Y, Komiya T, Sengoku R, Nakano Y, Uchino A, Sumikura H, Saito Y, Kanemaru K, Murayama S. Morimoto S, et al. PLoS One. 2017 Feb 6;12(2):e0171524. doi: 10.1371/journal.pone.0171524. eCollection 2017. PLoS One. 2017. PMID: 28166276 Free PMC article.
• The Lewy body in Parkinson's disease and related neurodegenerative disorders.
  Wakabayashi K, Tanji K, Odagiri S, Miki Y, Mori F, Takahashi H. Wakabayashi K, et al. Mol Neurobiol. 2013 Apr;47(2):495-508. doi: 10.1007/s12035-012-8280-y. Epub 2012 May 24. Mol Neurobiol. 2013. PMID: 22622968 Review.
• Diffuse Lewy body disease. Neuropathological and biochemical studies of six patients.
  Dickson DW, Davies P, Mayeux R, Crystal H, Horoupian DS, Thompson A, Goldman JE. Dickson DW, et al. Acta Neuropathol. 1987;75(1):8-15. doi: 10.1007/BF00686786. Acta Neuropathol. 1987. PMID: 3434218
• Age and duration related changes in muscle sympathetic nerve activity in Parkinson's disease.
  Shindo K, Watanabe H, Tanaka H, Ohashi K, Nagasaka T, Tsunoda S, Shiozawa Z. Shindo K, et al. J Neurol Neurosurg Psychiatry. 2003 Oct;74(10):1407-11. doi: 10.1136/jnnp.74.10.1407. J Neurol Neurosurg Psychiatry. 2003. PMID: 14570835 Free PMC article.

References

1. 1. J Neurol Sci. 1971 Dec;14(4):427-55 - PubMed
2. 1. Arch Neurol. 1969 Dec;21(6):615-9 - PubMed
3. 1. Acta Physiol Scand Suppl. 1965;:SUPPL 247:1-36 - PubMed
4. 1. Life Sci. 1965 Jul;4(13):1275-9 - PubMed
5. 1. Am J Pathol. 1959 Nov-Dec;35:1117-33 - PubMed

MeSH terms

Substances