Specialization and evolution of endogenous small RNA pathways - PubMed (original) (raw)

Review

doi: 10.1038/nrg2179.

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Review

Specialization and evolution of endogenous small RNA pathways

Elisabeth J Chapman et al. Nat Rev Genet. 2007 Nov.

Abstract

The specificity of RNA silencing is conferred by small RNA guides that are processed from structured RNA or dsRNA. The core components for small RNA biogenesis and effector functions have proliferated and specialized in eukaryotic lineages, resulting in diversified pathways that control expression of endogenous and exogenous genes, invasive elements and viruses, and repeated sequences. Deployment of small RNA pathways for spatiotemporal regulation of the transcriptome has shaped the evolution of eukaryotic genomes and contributed to the complexity of multicellular organisms.

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