Heterogeneous association between engrailed-2 and autism in the CPEA network - PubMed (original) (raw)
. 2008 Mar 5;147B(2):187-93.
doi: 10.1002/ajmg.b.30585.
Elena Korvatska, Kristina Allen-Brady, Edwin H Cook Jr, Geraldine Dawson, Bernie Devlin, Annette Estes, Meghann Hennelly, Susan L Hyman, William M McMahon, Jeffrey Munson, Patricia M Rodier, Gerard D Schellenberg, Christopher J Stodgell, Hilary Coon
Affiliations
- PMID: 17948868
- DOI: 10.1002/ajmg.b.30585
Heterogeneous association between engrailed-2 and autism in the CPEA network
Camille W Brune et al. Am J Med Genet B Neuropsychiatr Genet. 2008.
Abstract
Autism is a neurodevelopmental disorder characterized by an early onset of abnormal social, communicative, and repetitive behavior. Engrailed-2 (EN2) was identified as an autism candidate gene because its influence on cerebellar development in mice parallels neurodevelopmental abnormalities seen in individuals with autism. Studies investigating association between markers at EN2 (chr7q36), a location associated with language disorders, and autism reveal mixed findings. Two positive reports revealed association with two intronic SNPs. Since the associated SNPs were in high linkage disequilibrium and shared similar minor allele frequencies, we chose to test whether one of the SNPs (rs1861972) was associated with autism in three recruiting sites from the NIH Collaborative Programs of Excellence in Autism (CPEA) network. A recessive model revealed significant association with broad autism spectrum disorder. Site specific analyses indicated differential allele transmission by site, despite similar ethnicity, and parental genotypes, suggesting the SNP may contribute to various risk haplotypes. No significant association with autism was found under an additive model for either a broad (autism spectrum disorder) or a narrow (autistic disorder) diagnostic group. Although our findings were not as robust as the previous studies, they suggest that rs1861972 may influence the risk for autism spectrum disorders. Future studies investigating EN2 should consider how the association of variants in this gene with autism could be influenced by differences in phenotype and possible interactions with genotypes at other autism candidate genes.
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