Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis - PubMed (original) (raw)
Review
Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis
Manuel Tena-Sempere. Vitam Horm. 2008.
Abstract
Identification of ghrelin in late 1999, as the endogenous ligand of the growth hormone secretagogue receptor (GHSR), opened up a new era in our understanding of the regulatory mechanisms of several neuroendocrine systems, including growth and energy homeostasis. Based on similarities with other endocrine integrators and its proposed role as signal for energy insufficiency, it appeared tempting to hypothesize that ghrelin might also operate as regulator of reproductive function. Yet, contrary to other of its biological actions the reproductive "dimension" of ghrelin has remained largely unexplored. Nonetheless, experimental evidence, coming mostly from animal studies, have been gathered during the last years suggesting that ghrelin may actually function as a metabolic modulator of the gonadotropic axis, with predominant inhibitory effects in line with its role as signal of energy deficit. These effects likely include inhibition of luteinizing hormone (LH) secretion (which has been reported in different species and developmental stages), as well as partial suppression of normal puberty onset. In addition, expression and/or direct gonadal actions of ghrelin have been reported in the human, rat, and chicken. Altogether, those findings document a novel reproductive facet of ghrelin, which may cooperate with other neuroendocrine integrators, as leptin, in the joint control of energy balance and reproduction.
Similar articles
- Ghrelin and reproduction: a novel signal linking energy status and fertility?
Barreiro ML, Tena-Sempere M. Barreiro ML, et al. Mol Cell Endocrinol. 2004 Oct 29;226(1-2):1-9. doi: 10.1016/j.mce.2004.07.015. Mol Cell Endocrinol. 2004. PMID: 15488999 Review. - Ghrelin as a pleotrophic modulator of gonadal function and reproduction.
Tena-Sempere M. Tena-Sempere M. Nat Clin Pract Endocrinol Metab. 2008 Dec;4(12):666-74. doi: 10.1038/ncpendmet1003. Epub 2008 Nov 4. Nat Clin Pract Endocrinol Metab. 2008. PMID: 18981992 Review. - Exploring the role of ghrelin as novel regulator of gonadal function.
Tena-Sempere M. Tena-Sempere M. Growth Horm IGF Res. 2005 Apr;15(2):83-8. doi: 10.1016/j.ghir.2005.02.001. Growth Horm IGF Res. 2005. PMID: 15809012 Review. - Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies.
Fernández-Fernández R, Tena-Sempere M, Navarro VM, Barreiro ML, Castellano JM, Aguilar E, Pinilla L. Fernández-Fernández R, et al. Neuroendocrinology. 2005;82(5-6):245-55. doi: 10.1159/000092753. Epub 2006 Apr 20. Neuroendocrinology. 2005. PMID: 16721030 - Role of ghrelin in reproduction.
García MC, López M, Alvarez CV, Casanueva F, Tena-Sempere M, Diéguez C. García MC, et al. Reproduction. 2007 Mar;133(3):531-40. doi: 10.1530/REP-06-0249. Reproduction. 2007. PMID: 17379649 Review.
Cited by
- Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits.
Fonseca PAS, Suárez-Vega A, Arranz JJ, Gutiérrez-Gil B. Fonseca PAS, et al. Genet Sel Evol. 2024 May 21;56(1):40. doi: 10.1186/s12711-024-00910-w. Genet Sel Evol. 2024. PMID: 38773423 Free PMC article. - Nonadditive and allele-specific expression of ghrelin in hybrid tilapia.
Zhong H, Ren B, Lou C, Zhou Y, Luo Y, Xiao J. Zhong H, et al. Front Endocrinol (Lausanne). 2023 Dec 13;14:1292730. doi: 10.3389/fendo.2023.1292730. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 38152137 Free PMC article. - Ameliorative effects of aerobic training in girls with precocious puberty: role of leptin and ghrelin.
Najafi R, Heidarianpour A, Shokri E, Shokri B. Najafi R, et al. Sci Rep. 2023 Sep 21;13(1):15732. doi: 10.1038/s41598-023-42828-1. Sci Rep. 2023. PMID: 37735188 Free PMC article. - Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids.
Ibrahim I, Syamala S, Ayariga JA, Xu J, Robertson BK, Meenakshisundaram S, Ajayi OS. Ibrahim I, et al. Metabolites. 2022 Dec 10;12(12):1247. doi: 10.3390/metabo12121247. Metabolites. 2022. PMID: 36557285 Free PMC article. Review. - Gonadotropin Inhibitory Hormone and Its Receptor: Potential Key to the Integration and Coordination of Metabolic Status and Reproduction.
Bédécarrats GY, Hanlon C, Tsutsui K. Bédécarrats GY, et al. Front Endocrinol (Lausanne). 2022 Jan 13;12:781543. doi: 10.3389/fendo.2021.781543. eCollection 2021. Front Endocrinol (Lausanne). 2022. PMID: 35095760 Free PMC article. Review.