A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells - PubMed (original) (raw)
doi: 10.1038/ni1541. Epub 2007 Nov 11.
Affiliations
- PMID: 17994022
- DOI: 10.1038/ni1541
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
Amit Awasthi et al. Nat Immunol. 2007 Dec.
Abstract
Regulatory T cells (T(reg) cells) expressing the transcription factor Foxp3 are key in maintaining the balance of immune homeostasis. However, distinct induced T regulatory type 1 (Tr1) cells that lack Foxp3 expression also regulate T cell function, mainly by producing the immunosuppressive cytokine interleukin 10 (IL-10). However, the factors required for the induction of IL-10-producing suppressive T cells are not fully understood. Here we demonstrate that dendritic cells modified by T(reg) cells induced the generation of IL-10-producing Tr1 cells. The differentiation of naive CD4+ T cells into IL-10-producing cells was mediated by IL-27 produced by the T(reg) cell-modified dendritic cells, and transforming growth factor-beta amplified the generation of induced IL-10+ Tr1 cells by IL-27. Thus, IL-27 and transforming growth factor-beta promote the generation of IL-10-producing Tr1 cells.
Comment in
- IL-10 or not IL-10: that is the question.
Jankovic D, Trinchieri G. Jankovic D, et al. Nat Immunol. 2007 Dec;8(12):1281-3. doi: 10.1038/ni1207-1281. Nat Immunol. 2007. PMID: 18026076 No abstract available.
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