Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes - PubMed (original) (raw)
Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes
Mona Zimmermann et al. J Hepatol. 2008 Jan.
Abstract
Background/aims: Hepatitis C virus leads to chronic hepatitis in the majority of infected individuals. The mechanism of viral persistence is not completely understood. Hepatitis C virus core protein is produced within hepatocytes and is secreted during HCV infection. Our study characterizes the effects of core protein on T cell priming in mice.
Methods: We used a system of antigen-specific in vitro priming of CD4(+) and CD8(+) T cells by myeloid dendritic cells, hepatoma cells or primary hepatocytes. Core protein was either added to the cultures or expressed by antigen-presenting cells.
Results: Antigen-presenting cells treated with core protein showed reduced surface expression of major histocompatibility molecules. Myeloid dendritic cells showed also reduced expression of costimulatory molecules. CD4(+) and CD8(+) T cells primed by these cells showed defects in activation, proliferation, and cytokine production. Importantly, CD4(+) and also CD8(+) T cells primed in the presence of core protein showed an increase in interleukin-10 production resembling the phenotype of regulatory T cells.
Conclusions: Hepatitis C virus core protein inhibits priming of antigen-specific CD4(+) and CD8(+) T cell responses by downregulation of major histocompatibility molecules and costimulatory molecules on antigen-presenting cells and induces development of IL-10-producing T cells.
Comment in
- Hepatitis C core protein - the "core" of immune deception?
Szabo G, Dolganiuc A. Szabo G, et al. J Hepatol. 2008 Jan;48(1):8-11. doi: 10.1016/j.jhep.2007.10.005. Epub 2007 Nov 8. J Hepatol. 2008. PMID: 18023495 No abstract available.
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