Effect of oral estrogen on substrate utilization in postmenopausal women - PubMed (original) (raw)

Clinical Trial

Effect of oral estrogen on substrate utilization in postmenopausal women

Rebecca Lwin et al. Fertil Steril. 2008 Oct.

Free article

Abstract

We tested the hypothesis that a 2-month intervention with unopposed oral conjugated equine estrogens (0.625 mg/d) would decrease lipid oxidation, as assessed by 24-hour, whole-room, indirect calorimetry in 14 postmenopausal women. Estrogen (E) treatment was associated with declines in both 24-hour and postprandial lipid oxidation and an increase in fat mass (mean [+/-SD] 2-month difference 1.1 +/- 1.0 kg; mean 6-month difference 1.8 +/- 2.2 kg), suggesting that, on an acute basis, oral E may increase adiposity by limiting lipid oxidation.

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