Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae - PubMed (original) (raw)

. 2007 Aug 16;2(2):119-29.

doi: 10.1016/j.chom.2007.06.010.

Affiliations

• PMID: 18005726
• DOI: 10.1016/j.chom.2007.06.010

Free article

Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae

Claudia Lupp et al. Cell Host Microbe. 2007.

Free article

Abstract

While the normal microbiota has been implicated as a critical defense against invading pathogens, the impact of enteropathogenic infection and host inflammation on intestinal microbial communities has not been elucidated. Using mouse models of Citrobacter rodentium, which closely mimics human diarrheal pathogens inducing host intestinal inflammation, and Campylobacter jejuni infection, as well as chemically and genetically induced models of intestinal inflammation, we demonstrate that host-mediated inflammation in response to an infecting agent, a chemical trigger, or genetic predisposition markedly alters the colonic microbial community. While eliminating a subset of indigenous microbiota, host-mediated inflammation supported the growth of either the resident or introduced aerobic bacteria, particularly of the Enterobacteriaceae family. Further, assault by an enteropathogen and host-mediated inflammation combined to significantly reduce the total numbers of resident colonic bacteria. These findings underscore the importance of intestinal microbial ecosystems in infectious colitis and noninfectious intestinal inflammatory conditions, such as inflammatory bowel disease.

PubMed Disclaimer

Comment in

• Enteric infection and inflammation alter gut microbial ecology.
  Rawls JF. Rawls JF. Cell Host Microbe. 2007 Aug 16;2(2):73-4. doi: 10.1016/j.chom.2007.07.006. Cell Host Microbe. 2007. PMID: 18005720 Free PMC article.

Similar articles

• Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae.
  Lupp C, Robertson ML, Wickham ME, Sekirov I, Champion OL, Gaynor EC, Finlay BB. Lupp C, et al. Cell Host Microbe. 2007 Sep 13;2(3):204. doi: 10.1016/j.chom.2007.08.002. Cell Host Microbe. 2007. PMID: 18030708
• Enteric infection and inflammation alter gut microbial ecology.
  Rawls JF. Rawls JF. Cell Host Microbe. 2007 Aug 16;2(2):73-4. doi: 10.1016/j.chom.2007.07.006. Cell Host Microbe. 2007. PMID: 18005720 Free PMC article.
• TLR9 limits enteric antimicrobial responses and promotes microbiota-based colonisation resistance during Citrobacter rodentium infection.
  Yang H, Yu HB, Bhinder G, Ryz NR, Lee J, Yang H, Fotovati A, Gibson DL, Turvey SE, Reid GS, Vallance BA. Yang H, et al. Cell Microbiol. 2019 Jul;21(7):e13026. doi: 10.1111/cmi.13026. Epub 2019 May 7. Cell Microbiol. 2019. PMID: 30893495
• Animal models of inflammatory bowel disease: lessons from enteric infections.
  Eckmann L. Eckmann L. Ann N Y Acad Sci. 2006 Aug;1072:28-38. doi: 10.1196/annals.1326.008. Ann N Y Acad Sci. 2006. PMID: 17057188 Review.
• The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria.
  Blyth GAD, Connors L, Fodor C, Cobo ER. Blyth GAD, et al. Front Immunol. 2020 May 20;11:965. doi: 10.3389/fimmu.2020.00965. eCollection 2020. Front Immunol. 2020. PMID: 32508838 Free PMC article. Review.

Cited by

• Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation.
  Hughes ER, Winter MG, Alves da Silva L, Muramatsu MK, Jimenez AG, Gillis CC, Spiga L, Chanin RB, Santos RL, Zhu W, Winter SE. Hughes ER, et al. Elife. 2021 Jun 4;10:e58609. doi: 10.7554/eLife.58609. Elife. 2021. PMID: 34085924 Free PMC article.
• Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism.
  Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM. Vujkovic-Cvijin I, et al. Sci Transl Med. 2013 Jul 10;5(193):193ra91. doi: 10.1126/scitranslmed.3006438. Sci Transl Med. 2013. PMID: 23843452 Free PMC article.
• Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction.
  Lakhan SE, Kirchgessner A. Lakhan SE, et al. J Transl Med. 2011 Nov 24;9:202. doi: 10.1186/1479-5876-9-202. J Transl Med. 2011. PMID: 22115311 Free PMC article. Review.
• Bacteriotherapy for the treatment of intestinal dysbiosis caused by Clostridium difficile infection.
  Adamu BO, Lawley TD. Adamu BO, et al. Curr Opin Microbiol. 2013 Oct;16(5):596-601. doi: 10.1016/j.mib.2013.06.009. Epub 2013 Jul 15. Curr Opin Microbiol. 2013. PMID: 23866975 Free PMC article. Review.
• Gut dysbiosis induces the development of mastitis through a reduction in host anti-inflammatory enzyme activity by endotoxemia.
  Zhao C, Hu X, Bao L, Wu K, Zhao Y, Xiang K, Li S, Wang Y, Qiu M, Feng L, Meng X, Zhang N, Fu Y. Zhao C, et al. Microbiome. 2022 Dec 1;10(1):205. doi: 10.1186/s40168-022-01402-z. Microbiome. 2022. PMID: 36451232 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database