Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells - PubMed (original) (raw)

. 2007 Nov 16;318(5853):1141-3.

doi: 10.1126/science.1148536.

David E Anderson, Lisa Bregoli, William D Hastings, Nasim Kassam, Charles Lei, Rucha Chandwaskar, Jozsef Karman, Ee W Su, Mitsuomi Hirashima, Jeffrey N Bruce, Lawrence P Kane, Vijay K Kuchroo, David A Hafler

Affiliations

Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

Ana C Anderson et al. Science. 2007.

Abstract

CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is constitutively expressed on cells of the innate immune system in both mice and humans, and that it can synergize with Toll-like receptors. Moreover, an antibody agonist of Tim-3 acted as an adjuvant during induced immune responses, and Tim-3 ligation induced distinct signaling events in T cells and dendritic cells; the latter finding could explain the apparent divergent functions of Tim-3 in these cell types. Thus, by virtue of differential expression on innate versus adaptive immune cells, Tim-3 can either promote or terminate TH1 immunity and may be able to influence a range of inflammatory conditions.

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