A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor" - PubMed (original) (raw)

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• Novel NFKB2 Pathogenic Variants in Two Unrelated Patients with Common Variable Immunodeficiency.
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• Splenic Architecture and Function Requires Tight Control of Transmembrane TNF Expression.
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• Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway.
  Jie Z, Ko CJ, Wang H, Xie X, Li Y, Gu M, Zhu L, Yang JY, Gao T, Ru W, Tang SJ, Cheng X, Sun SC. Jie Z, et al. Sci Adv. 2021 Sep 3;7(36):eabh0609. doi: 10.1126/sciadv.abh0609. Epub 2021 Sep 3. Sci Adv. 2021. PMID: 34516909 Free PMC article.
• Inhibitory feedback control of NF-κB signalling in health and disease.
  Prescott JA, Mitchell JP, Cook SJ. Prescott JA, et al. Biochem J. 2021 Jul 16;478(13):2619-2664. doi: 10.1042/BCJ20210139. Biochem J. 2021. PMID: 34269817 Free PMC article. Review.