FIP200, a key signaling node to coordinately regulate various cellular processes - PubMed (original) (raw)

Review

FIP200, a key signaling node to coordinately regulate various cellular processes

Boyi Gan et al. Cell Signal. 2008 May.

Abstract

A central question in cell biology is how various cellular processes are coordinately regulated in normal cell and how dysregulation of the normal signaling pathways leads to diseases such as cancer. Recent studies have identified FIP200 as a crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways. This review will focus on the cellular functions of FIP200 and its interacting proteins, as well as the emerging roles of FIP200 in embryogenesis and cancer development. Further understanding of FIP200 function might provide novel therapeutic targets for human diseases such as cancer.

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Figures

Figure 1

Figure 1. Structural domains and binding proteins of FIP200

FIP200 consists of a putative nuclear localization signal (NLS) at N-terminus, a large coiled-coil (CC) domain and a leucine zipper (LZ) motif located at C-terminus. The proteins known to interact with specific regions of FIP200 are also shown.

Figure 2

Figure 2. FIP200 signaling pathway

FIP200 functions to regulate diverse cellular processes, including cell proliferation, cell spreading, cell migration, cell growth and cell survival. FIP200 suppresses cell proliferation by regulation of p53-p21, Cyclin D1, Rb1 and FAK pathways; FIP200 negatively regulates cell spreading and migration by its inhibition of FAK function; FIP200 promotes mTOR activation and cell growth through its interaction with TSC1-TSC2 complex; FIP200 positively regulates cell survival by its inhibition of Pyk2 activity and regulation of TNFα-JNK signaling cascade (see text for details).

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