The functional neuroanatomy of PTSD: a critical review - PubMed (original) (raw)
Review
The functional neuroanatomy of PTSD: a critical review
Israel Liberzon et al. Prog Brain Res. 2008.
Abstract
Neuroimaging provides an opportunity to understand core processes that mediate the experience of emotions in healthy individuals as well as dysregulation of these processes in conditions such as posttraumatic stress disorder (PTSD). The first decade of neuroimaging research produced symptom provocation, cognitive activation, and functional connectivity studies that highlighted the role of the medial prefrontal cortex (mPFC), amygdala, sublenticular extended amygdala (SLEA), and hippocampus, in mediating symptom formation in PTSD. There is a growing realization that a number of other psychological processes are relevant to PTSD, and they are emerging as a new focus of neuroimaging research. These include fear conditioning, habituation, and extinction; cognitive-emotional interactions; and self-related and social emotional processing. Neuroimaging findings are reviewed that suggest that the mPFC is implicated in a number of these processes. It is proposed that the mPFC plays a role in the "contextualization" of stimuli, and dysregulation of contextualization processes might play a key role in the generation of PTSD symptoms.
Similar articles
- Neuroimaging studies of emotional responses in PTSD.
Liberzon I, Martis B. Liberzon I, et al. Ann N Y Acad Sci. 2006 Jul;1071:87-109. doi: 10.1196/annals.1364.009. Ann N Y Acad Sci. 2006. PMID: 16891565 Review. - Amygdala, medial prefrontal cortex, and hippocampal function in PTSD.
Shin LM, Rauch SL, Pitman RK. Shin LM, et al. Ann N Y Acad Sci. 2006 Jul;1071:67-79. doi: 10.1196/annals.1364.007. Ann N Y Acad Sci. 2006. PMID: 16891563 Review. - A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder.
Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL. Shin LM, et al. Arch Gen Psychiatry. 2005 Mar;62(3):273-81. doi: 10.1001/archpsyc.62.3.273. Arch Gen Psychiatry. 2005. PMID: 15753240 - Alterations in brain structure and function associated with post-traumatic stress disorder.
Bremner JD. Bremner JD. Semin Clin Neuropsychiatry. 1999 Oct;4(4):249-55. doi: 10.153/SCNP00400249. Semin Clin Neuropsychiatry. 1999. PMID: 10553030 Review. - Altered pain processing in veterans with posttraumatic stress disorder.
Geuze E, Westenberg HG, Jochims A, de Kloet CS, Bohus M, Vermetten E, Schmahl C. Geuze E, et al. Arch Gen Psychiatry. 2007 Jan;64(1):76-85. doi: 10.1001/archpsyc.64.1.76. Arch Gen Psychiatry. 2007. PMID: 17199057
Cited by
- Prefrontal responses to Stroop tasks in subjects with post-traumatic stress disorder assessed by functional near infrared spectroscopy.
Yennu A, Tian F, Smith-Osborne A, J Gatchel R, Woon FL, Liu H. Yennu A, et al. Sci Rep. 2016 Jul 25;6:30157. doi: 10.1038/srep30157. Sci Rep. 2016. PMID: 27452397 Free PMC article. - Neurobiology of comorbid post-traumatic stress disorder and alcohol-use disorder.
Gilpin NW, Weiner JL. Gilpin NW, et al. Genes Brain Behav. 2017 Jan;16(1):15-43. doi: 10.1111/gbb.12349. Epub 2016 Nov 18. Genes Brain Behav. 2017. PMID: 27749004 Free PMC article. Review. - Dark-enhanced startle responses and heart rate variability in a traumatized civilian sample: putative sex-specific correlates of posttraumatic stress disorder.
Kamkwalala A, Norrholm SD, Poole JM, Brown A, Donley S, Duncan E, Bradley B, Ressler KJ, Jovanovic T. Kamkwalala A, et al. Psychosom Med. 2012 Feb-Mar;74(2):153-9. doi: 10.1097/PSY.0b013e318240803a. Epub 2012 Jan 27. Psychosom Med. 2012. PMID: 22286850 Free PMC article. - Decreased cardiac vagal control in drug-naïve patients with posttraumatic stress disorder.
Chang HA, Chang CC, Tzeng NS, Kuo TB, Lu RB, Huang SY. Chang HA, et al. Psychiatry Investig. 2013 Jun;10(2):121-30. doi: 10.4306/pi.2013.10.2.121. Epub 2013 May 30. Psychiatry Investig. 2013. PMID: 23798959 Free PMC article. - Neural systems for cognitive and emotional processing in posttraumatic stress disorder.
Brown VM, Morey RA. Brown VM, et al. Front Psychol. 2012 Oct 30;3:449. doi: 10.3389/fpsyg.2012.00449. eCollection 2012. Front Psychol. 2012. PMID: 23162499 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical