Use of animal models in the development of human vaccines - PubMed (original) (raw)
Review
Use of animal models in the development of human vaccines
Volker Gerdts et al. Future Microbiol. 2007 Dec.
Abstract
Over the past 100 years, animal infectious disease research has played a crucial role in the development of human vaccines. In fact, many of today's vaccines are based on utilizing animal pathogens, either in the form of an attenuated vaccine or as a vaccine vector. Vaccine development has become increasingly complex with chronic and newly emerging diseases, a demand for therapeutic vaccines for noninfectious diseases, extended vaccine in the neonate and the elderly, and increasing concerns regarding vaccine safety. Furthermore, the evaluation of quantity and quality of immune responses and the ability to efficiently translate the results of basic research into the clinic are critical to ensure that vaccines meet their therapeutic potential. Here, we review the importance of animal models for developing and testing novel human vaccines, discuss the limitations of existing animal models in knowledge translation, and summarize the needs and criteria for future animal models. We argue that efficient translation of basic vaccine research to clinical therapies will depend upon the availability of appropriate animal models to address each of the questions which arise during vaccine development.
Similar articles
- [Development of antituberculous drugs: current status and future prospects].
Tomioka H, Namba K. Tomioka H, et al. Kekkaku. 2006 Dec;81(12):753-74. Kekkaku. 2006. PMID: 17240921 Review. Japanese. - A strategic approach to vaccine development: animal models, monitoring vaccine efficacy, formulation and delivery.
Griffin JF. Griffin JF. Adv Drug Deliv Rev. 2002 Oct 4;54(6):851-61. doi: 10.1016/s0169-409x(02)00072-8. Adv Drug Deliv Rev. 2002. PMID: 12363434 Review. - Micro and nanoparticle-based delivery systems for vaccine immunotherapy: an immunological and materials perspective.
Leleux J, Roy K. Leleux J, et al. Adv Healthc Mater. 2013 Jan;2(1):72-94. doi: 10.1002/adhm.201200268. Epub 2012 Dec 6. Adv Healthc Mater. 2013. PMID: 23225517 Review. - Particle-based vaccines for transcutaneous vaccination.
Combadière B, Mahé B. Combadière B, et al. Comp Immunol Microbiol Infect Dis. 2008 Mar;31(2-3):293-315. doi: 10.1016/j.cimid.2007.07.015. Epub 2007 Oct 30. Comp Immunol Microbiol Infect Dis. 2008. PMID: 17915323 Review. - [Novel vaccines against M. tuberculosis].
Okada M. Okada M. Kekkaku. 2006 Dec;81(12):745-51. Kekkaku. 2006. PMID: 17240920 Review. Japanese.
Cited by
- Immunogenicity of an Inactivated Senecavirus A Vaccine with a Contemporary Brazilian Strain in Mice.
Barbosa AO, Gava D, Tochetto C, Ribeiro LC, Bastos APA, Morés MAZ, Schaefer R, de Lima M. Barbosa AO, et al. Vaccines (Basel). 2024 Jul 26;12(8):845. doi: 10.3390/vaccines12080845. Vaccines (Basel). 2024. PMID: 39203971 Free PMC article. - Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data.
Zohud O, Lone IM, Nashef A, Iraqi FA. Zohud O, et al. Animal Model Exp Med. 2023 Dec;6(6):537-558. doi: 10.1002/ame2.12367. Epub 2023 Dec 21. Animal Model Exp Med. 2023. PMID: 38129938 Free PMC article. Review. - The application, value, and impact of outcomes research in animal health and veterinary medicine.
Dewsbury DMA, Renter DG, Bradford BJ, DeDonder KD, Mellencamp M, Cernicchiaro N. Dewsbury DMA, et al. Front Vet Sci. 2022 Nov 29;9:972057. doi: 10.3389/fvets.2022.972057. eCollection 2022. Front Vet Sci. 2022. PMID: 36524226 Free PMC article. - Development of a rapid in vitro pre-screen for distinguishing effective liposome-adjuvant delivery systems.
Feather LAJ, Nadella V, Kastner E, Perrie Y, Hilton AC, Devitt A. Feather LAJ, et al. Sci Rep. 2022 Jul 20;12(1):12448. doi: 10.1038/s41598-022-14449-7. Sci Rep. 2022. PMID: 35859154 Free PMC article. - Assessing the risk of human-to-wildlife pathogen transmission for conservation and public health.
Fagre AC, Cohen LE, Eskew EA, Farrell M, Glennon E, Joseph MB, Frank HK, Ryan SJ, Carlson CJ, Albery GF. Fagre AC, et al. Ecol Lett. 2022 Jun;25(6):1534-1549. doi: 10.1111/ele.14003. Epub 2022 Mar 22. Ecol Lett. 2022. PMID: 35318793 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous