Transposons for cancer gene discovery: Sleeping Beauty and beyond - PubMed (original) (raw)

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Transposons for cancer gene discovery: Sleeping Beauty and beyond

Lara S Collier et al. Genome Biol. 2007.

Abstract

The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic studies and the potential use of additional transposable elements for somatic mutagenesis.

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Figures

Figure 1

Immunohistochemistry staining for SB transposase. Shown is immunohistochemistry staining for Sleeping Beauty (SB) transposase in (a) R26-SB11 mice and (b, c) CAGGS-SB10 mice. Anti-transposase immunoreactivity is indicated by brown stain and nuclei are counter-stained blue. In panel (a), essentially all nuclei are positive for transposase in intestine from a R26-SB11 mouse. In panel (b), rare nuclei are positive for transposase in this section of intestine from a CAGGS-SB10 mouse. In panel (c), variegated mesenchymal transposase expression (asterisk) is detected in muscular tissue from the digestive tract of a CAGGS-SB10 mouse.

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