Lack of effects of neutralization of parathyroid hormone-related protein on calcium homeostasis in neonatal mice - PubMed (original) (raw)
Lack of effects of neutralization of parathyroid hormone-related protein on calcium homeostasis in neonatal mice
S C Kukreja et al. J Bone Miner Res. 1991 Nov.
Abstract
Large quantities of parathyroid hormone-related protein (PTHrP) are present in the milk of various species. It has been suggested that PTHrP may play a role in neonatal calcium homeostasis. In the present study we evaluated the effect of neutralization of amino-terminal PTHrP activity by passive immunization in 1-day-old mouse pups. Neutralization of amino-terminal PTHrP activity had no significant effect on serum calcium or whole-body calcium content in the neonatal mice. In additional studies, we demonstrated that subcutaneous administration of PTHrP-(1-34) increased serum calcium, whereas oral administration had no significant effect in 3-day-old pups. The studies therefore demonstrate that the amino terminus of PTHrP may not play a significant role in neonatal calcium homeostasis. Local effects of PTHrP cannot be excluded by the results of the present study.
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