The biology of interleukin-2 - PubMed (original) (raw)
Review
The biology of interleukin-2
Thomas R Malek. Annu Rev Immunol. 2008.
Abstract
Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early paradigm in which IL-2 is central for protective immune responses. This change in thinking occurred when a T regulatory cell defect was shown to be responsible for the lethal autoimmunity associated with IL-2/IL-2R deficiency. This realization allowed investigators to explore immune responses in IL-2-nonresponsive mice rendered autoimmune-free. Such studies established that IL-2 sometimes contributes to optimal primary immune responses, but it is not mandatory. Emerging findings, however, suggest an essential role for IL-2 in immune memory. Here, the current understanding of the dual role of IL-2 in maintaining tolerance and contributing to immunity in vivo is reviewed with some emphasis on T regulatory cell production and homeostasis. Also discussed are implications of this new appreciation concerning the immunobiology of IL-2 with respect to targeting IL-2 or its receptor in immunotherapy.
Similar articles
- The main function of IL-2 is to promote the development of T regulatory cells.
Malek TR. Malek TR. J Leukoc Biol. 2003 Dec;74(6):961-5. doi: 10.1189/jlb.0603272. Epub 2003 Sep 2. J Leukoc Biol. 2003. PMID: 12960253 Review. - Regulatory T cells in health and disease.
Piccirillo CA. Piccirillo CA. Cytokine. 2008 Sep;43(3):395-401. doi: 10.1016/j.cyto.2008.07.469. Epub 2008 Aug 22. Cytokine. 2008. PMID: 18722786 Review. - [Suppressor T-cells: immunologic regulator cells and clinical perspectives].
Neumann-Haefelin C, Spangenberg HC, Thimme R, Blum HE. Neumann-Haefelin C, et al. Dtsch Med Wochenschr. 2004 Jul 23;129(30):1627-30. doi: 10.1055/s-2004-829004. Dtsch Med Wochenschr. 2004. PMID: 15257502 Review. German. - New Molecular and Cellular Mechanisms of Tolerance: Tolerogenic Actions of IL-2.
Pérol L, Piaggio E. Pérol L, et al. Methods Mol Biol. 2016;1371:11-28. doi: 10.1007/978-1-4939-3139-2_2. Methods Mol Biol. 2016. PMID: 26530792 Review. - Tolerance, not immunity, crucially depends on IL-2.
Malek TR, Bayer AL. Malek TR, et al. Nat Rev Immunol. 2004 Sep;4(9):665-74. doi: 10.1038/nri1435. Nat Rev Immunol. 2004. PMID: 15343366 Review.
Cited by
- The immune system as a self-centered network of lymphocytes.
Santori FR. Santori FR. Immunol Lett. 2015 Aug;166(2):109-16. doi: 10.1016/j.imlet.2015.06.002. Epub 2015 Jun 16. Immunol Lett. 2015. PMID: 26092524 Free PMC article. Review. - Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory TLR4-MyD88-NF-κB Signaling Pathway.
Zhang P, Xue Y, Cao Z, Guo Y, Pang X, Chen C, Zhang W. Zhang P, et al. Foods. 2024 Jun 13;13(12):1849. doi: 10.3390/foods13121849. Foods. 2024. PMID: 38928791 Free PMC article. - Lentiviral vector induces high-quality memory T cells via dendritic cells transduction.
Ku MW, Authié P, Nevo F, Souque P, Bourgine M, Romano M, Charneau P, Majlessi L. Ku MW, et al. Commun Biol. 2021 Jun 10;4(1):713. doi: 10.1038/s42003-021-02251-6. Commun Biol. 2021. PMID: 34112936 Free PMC article. - Therapeutic efficacy of monthly subcutaneous injection of daclizumab in relapsing multiple sclerosis.
Cohan S. Cohan S. Biologics. 2016 Sep 12;10:119-38. doi: 10.2147/BTT.S89218. eCollection 2016. Biologics. 2016. PMID: 27672308 Free PMC article. Review. - Genetics of rheumatoid arthritis: GWAS and beyond.
McAllister K, Eyre S, Orozco G. McAllister K, et al. Open Access Rheumatol. 2011 Jun 7;3:31-46. doi: 10.2147/OARRR.S14725. eCollection 2011. Open Access Rheumatol. 2011. PMID: 27790002 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources