Porphyrinmaleimides: towards thiol probes for cysteine residues in proteins - PubMed (original) (raw)

doi: 10.1021/bc700267f. Epub 2007 Dec 8.

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• PMID: 18067244
• DOI: 10.1021/bc700267f

Porphyrinmaleimides: towards thiol probes for cysteine residues in proteins

Yihui Chen et al. Bioconjug Chem. 2008 Jan.

Abstract

Porphyrinmaleimides were synthesized and characterized. The thiol-containing amino acid L-cysteine reacted with 58% yield with these porphyrins to form bioconjugate adducts. The new thiol-active reagents were labeled cytoplasmic cysteine 140 and 316 in rhodopsin (Rh), a G protein coupled receptor (GPCR).

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