Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction - PubMed (original) (raw)

doi: 10.1634/stemcells.2007-0484. Epub 2007 Dec 13.

Ana Armiñan, Jose Manuel García-Verdugo, Elisa Lledó, Amparo Ruiz, M Dolores Miñana, Jorge Sanchez-Torrijos, Rafael Payá, Vicente Mirabet, Francisco Carbonell-Uberos, Mauro Llop, Jose Anastasio Montero, Pilar Sepúlveda

Affiliations

• PMID: 18079433
• DOI: 10.1634/stemcells.2007-0484

Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction

Carolina Gandia et al. Stem Cells. 2008 Mar.

Abstract

Human dental pulp contains precursor cells termed dental pulp stem cells (DPSC) that show self-renewal and multilineage differentiation and also secrete multiple proangiogenic and antiapoptotic factors. To examine whether these cells could have therapeutic potential in the repair of myocardial infarction (MI), DPSC were infected with a retrovirus encoding the green fluorescent protein (GFP) and expanded ex vivo. Seven days after induction of myocardial infarction by coronary artery ligation, 1.5 x 10(6) GFP-DPSC were injected intramyocardially in nude rats. At 4 weeks, cell-treated animals showed an improvement in cardiac function, observed by percentage changes in anterior wall thickening left ventricular fractional area change, in parallel with a reduction in infarct size. No histologic evidence was seen of GFP+ endothelial cells, smooth muscle cells, or cardiac muscle cells within the infarct. However, angiogenesis was increased relative to control-treated animals. Taken together, these data suggest that DPSC could provide a novel alternative cell population for cardiac repair, at least in the setting of acute MI.

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