An investigation of predictors of renal insufficiency following treatment of hyperthyroidism in cats - PubMed (original) (raw)
An investigation of predictors of renal insufficiency following treatment of hyperthyroidism in cats
Melissa R Riensche et al. J Feline Med Surg. 2008 Apr.
Abstract
To determine if routine pre-treatment clinical data can be used to predict the development of overt renal insufficiency following treatment of feline hyperthyroidism, we studied retrospectively all non-azotemic cats undergoing treatment for hyperthyroidism at our hospital. Medical records were reviewed for signalment, clinical signs, and serum biochemical, hematologic and urinalysis parameters before and after treatment for hyperthyroidism. Two groups - cats that developed post-treatment renal insufficiency, and those that did not - were compared. No significant differences could be detected between the groups with respect to the parameters measured. Our study suggests that the results of routine pre-treatment clinical data cannot be used to reliably predict renal function after treatment for hyperthyroidism, validating the necessity of a methimazole trial prior to definitive therapy. The widely held belief that cats with pre-treatment urine specific gravity>1.035 are at less risk for development of renal azotemia after treatment of hyperthyroidism seems unwarranted.
Figures
Fig 1.
Box plots showing USG measurements in cats that did (group 2) or did not (group 1) develop overt renal insufficiency within 6 months of treatment of hyperthyroidism. The box represents the interquartile range from the 25th to the 75th percentile. The solid horizontal bar through the box represents the mean, and the 10th through 90th percentile is represented by the capped vertical bars.
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