Association between SORL1 and Alzheimer's disease in a genome-wide study - PubMed (original) (raw)

Association between SORL1 and Alzheimer's disease in a genome-wide study

Yan Meng et al. Neuroreport. 2007.

Abstract

Several studies have reported an association of Alzheimer's disease (AD) with polymorphic markers in SORL1. Data from a recently published genome-wide association study in AD have been made publicly available. We tested the association of AD with SORL1 in this dataset (Translational Genomics Research Institute; TGEN), which included 31 SORL1 single nucleotide polymorphisms (SNPs), eight of which overlapped the original study. Six SNPs, near the 3' region of SORL1 containing SNPs which were strongly associated with AD in previous studies, showed significant association in the TGEN dataset. These results provide an independent replication of the association between AD and SORL1.

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Figures

Figure 1

Figure 1

Linkage disequilibrium (LD) structure of SORL1. Relative locations of SNPs included in each dataset are shown on two parallel stick diagrams, with LD maps for the TGEN dataset located above and the north European familial AD dataset studied by Rogaeva et al. [1] below the gene structure. The measure of LD (D′) among all possible pairs of SNPs is shown graphically according to the shade of red where white represents very low D′ and dark red represents very high D′. High D′ estimates associated with a large confidence interval (most likely due to one of the alleles being rare) are denoted by blue squares.

References

    1. Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet. 2007;39(2):168–177. - PMC - PubMed
    1. Lee JH, Cheng R, Schupf N, Manly J, Lantigua R, Stern Y, et al. The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort. Arch Neurol. 2007;64(4):501–506. - PMC - PubMed
    1. Lee JH, Cheng R, Schupf N, Honig LS, Vonsattel GJ, Clark L, et al. The Association Between Genetic Variants in SORL1 and Autopsy-Confirmed Alzheimer’s Disease. Neurology. 2007 In press. - PMC - PubMed
    1. Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, et al. GAB2 alleles modify Alzheimer’s risk in APOE epsilon4 carriers. Neuron. 2007;54(5):713–720. - PMC - PubMed
    1. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21(2):263–265. - PubMed

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