Neonatal mortality and morbidity rates in late preterm births compared with births at term - PubMed (original) (raw)
Neonatal mortality and morbidity rates in late preterm births compared with births at term
Donald D McIntire et al. Obstet Gynecol. 2008 Jan.
Abstract
Objective: To analyze neonatal mortality and morbidity rates at 34, 35, and 36 weeks of gestation compared with births at term over the past 18 years at our hospital and to estimate the magnitude of increased risk associated with late preterm births compared with births later in gestation.
Methods: We performed a retrospective cohort study of births at our hospital over the past 18 years. The study included all liveborn singleton infants between 34 and 40 weeks of gestation and without anomalies that were delivered to women who received prenatal care in our hospital system. Neonatal outcomes for late preterm births were compared with those for infants delivered at 39 weeks.
Results: Late preterm singleton live births constituted approximately 9% of all deliveries at our hospital and accounted for 76% of all preterm births. Late preterm neonatal mortality rates per 1,000 live births were 1.1, 1.5, and 0.5 at 34, 35, and 36 weeks, respectively, compared with 0.2 at 39 weeks (P<.001). Neonatal morbidity was significantly increased at 34, 35, and 36 weeks, including ventilator-treated respiratory distress, transient tachypnea, grades 1 or 2 intraventricular hemorrhage, sepsis work-ups, culture-proven sepsis, phototherapy for hyperbilirubinemia, and intubation in the delivery room. Approximately 80% of late preterm births were attributed to idiopathic preterm labor or ruptured membranes and 20% to obstetric complications.
Conclusion: Late preterm births are common and associated with significantly increased neonatal mortality and morbidity compared with births at 39 weeks. Preterm labor was the most common cause (45%) for late preterm births.
Level of evidence: II.
Similar articles
- Perinatal outcomes associated with preterm birth at 33 to 36 weeks' gestation: a population-based cohort study.
Khashu M, Narayanan M, Bhargava S, Osiovich H. Khashu M, et al. Pediatrics. 2009 Jan;123(1):109-13. doi: 10.1542/peds.2007-3743. Pediatrics. 2009. PMID: 19117868 - Extreme preterm birth: onset of delivery and its effect on infant survival and morbidity.
Johanzon M, Odesjö H, Jacobsson B, Sandberg K, Wennerholm UB. Johanzon M, et al. Obstet Gynecol. 2008 Jan;111(1):42-50. doi: 10.1097/01.AOG.0000295866.97499.35. Obstet Gynecol. 2008. PMID: 18165391 - Associated factors and consequences of late preterm births: results from the 2004 Pelotas birth cohort.
Santos IS, Matijasevich A, Silveira MF, Sclowitz IK, Barros AJ, Victora CG, Barros FC. Santos IS, et al. Paediatr Perinat Epidemiol. 2008 Jul;22(4):350-9. doi: 10.1111/j.1365-3016.2008.00934.x. Paediatr Perinat Epidemiol. 2008. PMID: 18578748 - Short-term outcomes of infants born at 35 and 36 weeks gestation: we need to ask more questions.
Escobar GJ, Clark RH, Greene JD. Escobar GJ, et al. Semin Perinatol. 2006 Feb;30(1):28-33. doi: 10.1053/j.semperi.2006.01.005. Semin Perinatol. 2006. PMID: 16549211 Review. - Health issues of the late preterm infant.
Ramachandrappa A, Jain L. Ramachandrappa A, et al. Pediatr Clin North Am. 2009 Jun;56(3):565-77, Table of Contents. doi: 10.1016/j.pcl.2009.03.009. Pediatr Clin North Am. 2009. PMID: 19501692 Review.
Cited by
- Effect of antenatal corticosteroids on respiratory morbidity in singletons after late-preterm birth.
Gyamfi-Bannerman C, Gilbert S, Landon MB, Spong CY, Rouse DJ, Varner MW, Meis PJ, Wapner RJ, Sorokin Y, Carpenter M, Peaceman AM, O'Sullivan MJ, Sibai BM, Thorp JM, Ramin SM, Mercer BM; Eunice Kennedy Shriver National Institute of Child Health; Human Development (NICHD) Maternal-Fetal Medicine Units Network (MFMU). Gyamfi-Bannerman C, et al. Obstet Gynecol. 2012 Mar;119(3):555-9. doi: 10.1097/AOG.0b013e31824758f6. Obstet Gynecol. 2012. PMID: 22353953 Free PMC article. - Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia.
Chaiworapongsa T, Romero R, Korzeniewski SJ, Kusanovic JP, Soto E, Lam J, Dong Z, Than NG, Yeo L, Hernandez-Andrade E, Conde-Agudelo A, Hassan SS. Chaiworapongsa T, et al. Am J Obstet Gynecol. 2013 Apr;208(4):287.e1-287.e15. doi: 10.1016/j.ajog.2013.01.016. Epub 2013 Jan 17. Am J Obstet Gynecol. 2013. PMID: 23333542 Free PMC article. - Gestational age at birth and morbidity, mortality, and growth in the first 4 years of life: findings from three birth cohorts in Southern Brazil.
Barros FC, Rossello JL, Matijasevich A, Dumith SC, Barros AJ, dos Santos IS, Mota D, Victora CG. Barros FC, et al. BMC Pediatr. 2012 Oct 31;12:169. doi: 10.1186/1471-2431-12-169. BMC Pediatr. 2012. PMID: 23114098 Free PMC article. - Challenges in Using Progestin to Prevent Singleton Preterm Births: Current Knowledge and Clinical Advice.
Nelson DB, Fomina YY. Nelson DB, et al. Int J Womens Health. 2024 Jan 22;16:119-130. doi: 10.2147/IJWH.S394305. eCollection 2024. Int J Womens Health. 2024. PMID: 38283999 Free PMC article. Review. - Euglycemia after antenatal late preterm steroids: a multicenter, randomized controlled trial.
Battarbee AN, Ye Y, Szychowski JM, Casey BM, Tita AT, Boggess KA. Battarbee AN, et al. Am J Obstet Gynecol MFM. 2022 Jul;4(4):100625. doi: 10.1016/j.ajogmf.2022.100625. Epub 2022 Mar 26. Am J Obstet Gynecol MFM. 2022. PMID: 35346889 Free PMC article. Clinical Trial.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous