MicroRNA signature predicts survival and relapse in lung cancer - PubMed (original) (raw)

doi: 10.1016/j.ccr.2007.12.008.

Hsuan-Yu Chen, Gee-Chen Chang, Chih-Yi Chen, Huei-Wen Chen, Sher Singh, Chiou-Ling Cheng, Chong-Jen Yu, Yung-Chie Lee, Han-Shiang Chen, Te-Jen Su, Ching-Cheng Chiang, Han-Ni Li, Qi-Sheng Hong, Hsin-Yuan Su, Chun-Chieh Chen, Wan-Jiun Chen, Chun-Chi Liu, Wing-Kai Chan, Wei J Chen, Ker-Chau Li, Jeremy J W Chen, Pan-Chyr Yang

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MicroRNA signature predicts survival and relapse in lung cancer

Sung-Liang Yu et al. Cancer Cell. 2008 Jan.

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Abstract

We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.

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