Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population - PubMed (original) (raw)
doi: 10.1159/000112852. Epub 2008 Jan 4.
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- PMID: 18176077
- DOI: 10.1159/000112852
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Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population
Yolande A L Pijnenburg et al. Dement Geriatr Cogn Disord. 2008.
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Abstract
Background/aims: The goal of the present study was to evaluate the diagnostic accuracy of the core diagnostic criteria for frontotemporal dementia (FTD) [Neary D, et al: Neurology 1998;51:1546-1554] within a memory clinic population.
Methods: The 5 core diagnostic criteria for FTD were operationalised in an informant-based written questionnaire. For a diagnosis of FTD the total clinical picture was weighted with findings on additional investigations and possible exclusion criteria, with follow-up of at least 1 year.
Results: The operationalised core criteria for FTD had a sensitivity of 79% (95% CI = 57-92) and a specificity of 90% (95% CI = 85-94).
Conclusion: The core diagnostic criteria for FTD applied in a caregiver questionnaire have good diagnostic accuracy among subjects without advanced dementia attending a memory clinic. This stresses the importance of the informant-based history in the differential diagnosis of dementia.
Copyright (c) 2008 S. Karger AG, Basel.
Comment in
- Validation of diagnostic criteria for frontotemporal dementia.
Kertesz A. Kertesz A. Nat Clin Pract Neurol. 2008 Jul;4(7):362-3. doi: 10.1038/ncpneuro0827. Epub 2008 Jun 3. Nat Clin Pract Neurol. 2008. PMID: 18523428 No abstract available.
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