Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up - PubMed (original) (raw)
Multicenter Study
Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up
Jing Xie et al. BMJ. 2008.
Abstract
Objectives: To provide estimates of survival after onset of dementia by age, sex, self reported health, disability, and severity of cognitive impairment.
Design: Analysis of participants from prospective population based cohort study in 1991-2003, with follow-up of dementia status in all individuals after two and six years (in one centre) and 10 years and in subsamples additionally at six and eight years and mortality until 2005.
Setting: Multicentre population based study in England and Wales: two rural and three urban centres.
Participants: 438 participants who developed dementia from a population based study of 13 004 individuals aged 65 years and over drawn from primary care population registers.
Main outcome measures: Sociodemographic factors, cognitive function, specific health conditions, and self reported health collected at each interview. Cox's proportional hazards regression models were used to identify predictors of mortality from the selected variables in people who received diagnosis of dementia according the study's criteria.
Results: By December 2005, 356 of the 438 (81%) participants who developed dementia during the study had died. Estimated median survival time from onset of dementia to death was 4.1 years (interquartile range 2.5-7.6) for men and 4.6 years (2.9-7.0) for women. There was a difference of nearly seven years in survival between the younger old and the oldest people with dementia: 10.7 (25th centile 5.6) for ages 65-69; 5.4 (interquartile range 3.4-8.3) for ages 70-79; 4.3 (2.8-7.0) for ages 80-89, and 3.8 (2.3-5.2) years for ages > or =90. Significant factors that predicted mortality in the presence of dementia during the follow-up included sex, age of onset, and disability.
Conclusion: These analyses give a population based estimated median survival for incident dementia of 4.5 years. Such estimates can be used for prognosis and planning for patients, carers, service providers, and policy makers.
Conflict of interest statement
Competing interests: None declared.
Figures
Flowchart of incident dementia cases
Comment in
- Caring for people with dementia.
Downs M, Bowers B. Downs M, et al. BMJ. 2008 Feb 2;336(7638):225-6. doi: 10.1136/bmj.39429.434907.80. Epub 2008 Jan 10. BMJ. 2008. PMID: 18187697 Free PMC article. - Age, sex, and functional impairment predicted risk for mortality in incident dementia at 14 years.
Molloy DW. Molloy DW. ACP J Club. 2008 Jul;149(1):13. ACP J Club. 2008. PMID: 18624381 No abstract available. - Age, sex, and functional impairment predicted risk of mortality in incident dementia at 14 years.
Molloy DW. Molloy DW. Evid Based Med. 2008 Aug;13(4):120. doi: 10.1136/ebm.13.4.120. Evid Based Med. 2008. PMID: 18667679 No abstract available.
References
- Comas-Herrera A, Wittenberg R, Pickard L, Knapp M, MRC-CFAS. Cognitive impairment in older people: its implications for future demand for services and costs Canterbury: Personal Social Services Research Unit, 2003. (Discussion paper 1728)
- Waring SC, Doody RS, Pavlik VN, Massman PJ, Chan W. Survival among patients with dementia from a large multi-ethnic population. Alzheimer Dis Assoc Disord 2005;19:178-83. - PubMed
- Fitzpatrick AL, Kuller LH, Lopez OL, Kawas CH, Jagust W. Survival following dementia onset: Alzheimer’s disease and vascular dementia. J Neurol Sci 2005;229-30:43-9. - PubMed
- Freels S, Nyenhuis DL, Gorelick PB. Predictors of survival in African American patients with AD, VaD, or stroke without dementia. Neurology 2002;59:1146-53. - PubMed
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