CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator - PubMed (original) (raw)
doi: 10.1038/ni1554. Epub 2008 Jan 13.
Affiliations
- PMID: 18193050
- DOI: 10.1038/ni1554
CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator
Guifang Cai et al. Nat Immunol. 2008 Feb.
Erratum in
- Nat Immunol. 2008 May;9(5):567
Abstract
CD160, a glycosylphosphatidylinositol-anchored member of the immunoglobulin superfamily, is expressed on both cytolytic lymphocytes and some unstimulated CD4+ T cells. Here we show that CD160 expression was increased after activation of human CD4+ T cells and that crosslinking CD160 with monoclonal antibody strongly inhibited CD3- and CD28-mediated activation. We found that herpesvirus entry mediator (HVEM) was a ligand of CD160 that acted as a 'bidirectional switch' for T cell activation, producing a positive or negative outcome depending on the engagement of HVEM by CD160 and known HVEM ligands such as B and T lymphocyte attenuator (BTLA) and the T lymphocyte receptor LIGHT. Inhibition of CD4+ T cell activation by HVEM-transfected cells was dependent on CD160 and BTLA; when the cysteine-rich domain 1 of HVEM was deleted, this inhibition was lost, resulting in strong T cell activation. CD160 thus serves as a negative regulator of CD4+ T cell activation through its interaction with HVEM.
Comment in
- CD160 and BTLA: LIGHTs out for CD4+ T cells.
Kaye J. Kaye J. Nat Immunol. 2008 Feb;9(2):122-4. doi: 10.1038/ni0208-122. Nat Immunol. 2008. PMID: 18204424 No abstract available.
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